66719-03-7

Basic information

• Product Name: 2-(6-methoxynaphthalen-2-yl)-N-phenylpropanamide
• CAS NO: 66719-03-7
• Molecular Weight: 305.376
• Mol File: 66719-03-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(6-methoxynaphthalen-2-yl)-N-phenylpropanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-methoxynaphthalen-2-yl)-N-phenylpropanamide(66719-03-7)
• EPA Substance Registry System: 2-(6-methoxynaphthalen-2-yl)-N-phenylpropanamide(66719-03-7)

Safety Data

• Hazardous Substances Data: 66719-03-7(Hazardous Substances Data)

Upstream product

• 201230-82-2 carbon monoxide 
• 63444-51-9 2-methoxy-6-vinylnapthalene 
• 62-53-3 aniline 

Relevant articles and documents

Asymmetric Markovnikov Hydroaminocarbonylation of Alkenes Enabled by Palladium-Monodentate Phosphoramidite Catalysis

A palladium-catalyzed asymmetric Markovnikov hydroaminocarbonylation of alkenes with anilines has been developed for the atom-economical synthesis of 2-substituted propanamides bearing an α-stereocenter. A novel phosphoramidite ligand L16 was discovered which exhibited very high reactivity and selectivity in the reaction. This asymmetric Markovnikov hydroaminocarbonylation employs readily available starting materials and tolerates a wide range of functional groups, thus providing a facile and straightforward method for the regio- and enantioselective synthesis of 2-substituted propanamides under ambient conditions. Mechanistic studies revealed that the reaction proceeds through a palladium hydride pathway.