66769-61-7

Basic information

• Product Name: Benzene, 1-(iodomethyl)-3,5-dimethoxy-
• CAS NO: 66769-61-7
• Molecular Formula: C9H11IO2
• Molecular Weight: 278.09
• Mol File: 66769-61-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(iodomethyl)-3,5-dimethoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(iodomethyl)-3,5-dimethoxy-(66769-61-7)
• EPA Substance Registry System: Benzene, 1-(iodomethyl)-3,5-dimethoxy-(66769-61-7)

Safety Data

• Hazardous Substances Data: 66769-61-7(Hazardous Substances Data)

Upstream product

• 877-88-3 3,5-dimethoxybenzyl bromide 
• 6652-32-0 3,5-dimethoxybenzylchloride 
• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 2150-37-0 methyl 3,5-dimethoxybenzoate 
• 705-76-0 3,5-dimethoxybenzyl alcohol 

Downstream Products

• 537-42-8 3,5-dimethoxy-4'-hydroxy-trans-stilbene 
• 196926-65-5 6,8-dihydroxy-2-(2-oxopentyl)benzoic acid 
• 196926-69-9 2-(3,5-dimethoxybenzyl)pentanoic acid 
• 196926-63-3 2,4-dimethoxy-6-(2-oxo-pentyl)-benzoic acid 
• 210629-90-6 (2S,5S)-2-tert-Butyl-5-(3,5-dimethoxy-benzyl)-5-isopropyl-4-methoxy-2,5-dihydro-imidazole-1-carboxylic acid tert-butyl ester 
• 210629-89-3 (2S,5R)-5-Allyl-2-tert-butyl-5-(3,5-dimethoxy-benzyl)-4-methoxy-2,5-dihydro-imidazole-1-carboxylic acid tert-butyl ester 
• 4179-19-5 1,3-dimethoxy-5-methylbenzene 
• 73569-69-4 1-methylmethoxy-3,5-dimethoxybenzene 
• 196926-60-0 2-(3,5-Dimethoxy-benzyl)-pentanoic acid ethyl ester 

Relevant articles and documents

Rhodium-Catalyzed Generation of Anhydrous Hydrogen Iodide: An Effective Method for the Preparation of Iodoalkanes

The preparation of anhydrous hydrogen iodide directly from molecular hydrogen and iodine using a rhodium catalyst is reported for the first time. The anhydrous hydrogen iodide generated was proven to be highly active in the transformations of alkenes, phenyl aldehydes, alcohols, and cyclic ethers to the corresponding iodoalkanes. Therefore, the present methodology not only has provided convenient access to anhydrous hydrogen iodide but also offers a practical preparation method for various iodoalkanes in excellent atom economy.

Synthesis of (±)-Hiburipyranone, a Cytotoxic Metabolite of Marine Sponge Mycale adhaerens

Hiburipyranone, a cytotoxic metabolite of the marine sponge, Mycale adhaerens, was synthesized as a racemate.

Antitumor agents. 120. New 4-substituted benzylamine and benzyl ether derivatives of 4'-O-demethylepipodophyollotoxin as potent inhibitors of human DNA topoisomerase II

A number of new 4'-O-demethylepipodophyllotoxin derivatives possessing various 4β-N- or 4β-O-benzyl groups have been synthesized and evaluated for their inhibitory activity against the human DNA topoisomerase II as well as for their activity in causing cellular protein-linked DNA breakage. The 4β-N-benzyl derivatives 9-22 are, in general, as active or more active than etoposide (1). The most active compounds are 14, 16, and 17, which are more than 2-fold more potent than 1. The results indicated that a basic unsubstituted 4β-benzylamino moiety is structurally required for the enhanced activity. Replacement of the benzyl nitrogen with oxygen gave compounds (23 and 24) which are inactive. The ability of these compounds to inhibit human DNA topoisomerase II and to cause protein-linked DNA breakage appears to have no direct correlation with cytotoxicity in KB cells.