66774-80-9Relevant articles and documents
Synthesis and biological evaluation of calcioic acid
Arnold, Leggy A.,Di Milo, Elliot S.,Mutchie, Tania R.,Yu, Olivia B.
, (2019/11/25)
Herein, we describe the synthesis of calcioic acid following a recently developed synthetic strategy for calcitroic acid. Several improvements to reaction conditions were made, which resulted in higher yields. The improved workup and isolation procedures
Carborane-based design of a potent Vitamin D receptor agonist
Otero, Rocio,Seoane, Samuel,Sigüeiro, Rita,Belorusova, Anna Y.,Maestro, Miguel A.,Pérez-Fernández, Roman,Rochel, Natacha,Mouri?o, Antonio
, p. 1033 - 1037 (2016/02/05)
The vitamin D nuclear receptor (VDR) is a potential target for cancer therapy. It is expressed in many tumors and its ligand shows anticancer actions. To combine these properties with the application of boron neutron capture therapy (BNCT), we design and
Synthesis and preliminary biological evaluation of new antiproliferative aromatic analogues of 1α,25-dihydroxyvitamin D3
Thomas, Emmanuel,Brion, Jean-Daniel,Peyrat, Jean-Fran?ois
, p. 381 - 393 (2014/11/07)
In an effort to develop novel vitamin D3 analogues, a series of aromatic compounds was synthetized, using efficient Negishi cross coupling between alkenylzinc reagents of the C,D-ring moiety of vitamin D3, and various substituted aromatic halides as A-ring mimics. The study aimed at exploring the influence of the replacement of the original vitamin D3 diene by a styrene unit on the biological activities. Potency in the induction of the differentiation of HL-60 cells for the lead compound 36 was 12 fold less important than calcitriol correlating with a weaker binding affinity for VDR.