66849-11-4

Basic information

• Product Name: Benzoyl chloride, 2-(1-methylethoxy)- (9CI)
• Synonyms: Benzoyl chloride, 2-(1-methylethoxy)- (9CI);2-propan-2-yloxybenzoyl chloride
• CAS NO: 66849-11-4
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.64614
• Product Categories: ACIDHALIDE
• Mol File: 66849-11-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoyl chloride, 2-(1-methylethoxy)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoyl chloride, 2-(1-methylethoxy)- (9CI)(66849-11-4)
• EPA Substance Registry System: Benzoyl chloride, 2-(1-methylethoxy)- (9CI)(66849-11-4)

Safety Data

• Hazardous Substances Data: 66849-11-4(Hazardous Substances Data)

Upstream product

• 57009-13-9 methyl-2-isopropoxybenzoate 
• 119-36-8 methyl salicylate 
• 13205-46-4 4-isopropoxybenzoic acid 
• 63635-26-7 2-isopropoxybenzoic acid 

Downstream Products

• 318730-14-2 (6R,7R)-7-(2-Isopropoxy-benzoylamino)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 318730-48-2 (6R,7R)-7-(2-Isopropoxy-benzoylamino)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-benzhydryloxycarbonyl-benzyl ester 
• 1622869-28-6 C₂₄H₂₁F₃N₂O₄ 
• 1622869-18-4 C₂₄H₂₄N₂O₃ 
• 1334308-65-4 C₂₄H₃₉N₃O₂ 
• 938193-71-6 N-(4-cyano-3-trifluoromethyl-phenyl)-2-isopropoxy-benzamide 
• 168163-02-8 (Z)-[4,4-difluoro-1-[4-(2-isopropoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetic acid 
• 168162-78-5 methyl (Z)-[4,4-difluoro-1-[4-(2-isopropoxybenzoyl)amino]benzoyl-2,3,4,5-tetrahydro-1H-1-benzazepin-5-ylidene]acetate 
• 206855-17-6 (6R,7R)-7-(2-Isopropoxy-benzoylamino)-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylsulfanylmethyl)-8-oxo-5-oxa-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 168626-59-3 2-isopropyloxy-4'-[(5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl)carbonyl]benzanilide 
• 63746-15-6 2-(2-isopropoxy-phenyl)-4-oxo-4H-benzo[d][1,3]oxazine-6-carboxylic acid 

Relevant articles and documents

Metal-free Synthesis of Spiro-2,2′-benzo[b]furan-3,3′-ones via PhI(OAc)2-Mediated Cascade Spirocyclization

Treating the benzyl protected 3-hydroxy-1,3-bis(2-hydroxyphenyl)prop-2-en-1-ones solely with PhI(OAc)2 (PIDA) in DCE at room temperature readily furnished the seldom studied spiro-2,2′-benzo[b]furan-3,3′-ones in satisfactory to excellent yields. The hypervalent iodine reagent enables the metal-free cascade spirocyclization resulting in the dual oxidative C?O bond formation. (Figure presented.).

Preparation of non-peptide, highly potent and selective antagonists of arginine vasopressin V1a receptor by introduction of alkoxy groups

A series of compounds structurally related to 4′-[(4,4-difluoro-5- methylidene-2,3,4,5-tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]benzanilide were synthesized and evaluated for arginine vasopressin (AVP) antagonistic activity. Compounds with alkoxy groups (especially ethoxy group) at the 2′-position of benzanilide possessed potent affinity and selectivity for the V1A receptor versus V2 receptor. Further study has shown that the introduction of 4,4-dimethylaminopiperidino and morpholino groups at carbonylmethylene exhibited more potent affinity and selectivity for V 1A receptors. Consequently, we found that the (Z)-4′-({4,4- Difluoro-5-[(4-dimethylaminopiperidino) carbonylmethylene]-2,3,4,5-tetrahydro- 1H-1-benzoazepin-1-yl}carbonyl)-2-ethoxybenzanilide monohydrochloride (8d) and the (Z)-4′-[(4,4-Difluoro-5-morpholinocarbamoylethylene-2,3,4,5- tetrahydro-1H-1-benzoazepin-1-yl)carbonyl]-2-ethoxybenzanilide (8q) exhibited potent and selective V1A receptor antagonist activity. The synthesis and pharmacological properties of these compounds are detailed in this paper.

Ester composition

The invention relates to a method for preparing an ester composition in which at least one activated phenolic ether group of a molecule is reacted with at least one haloformyl group of another molecule.