669008-25-7

Basic information

• Product Name: 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE
• Synonyms: 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE;CYCLOPROPANESULFONAMIDE, N-(1,1-DIMETHYLETHYL)-1-METHYL-;N-TERT-BUTYL-1-METHYLCYCLOPROPANE-1-SULFONAMIDE;EOS-60886
• CAS NO: 669008-25-7
• Molecular Formula: C₈H₁₇NO₂S
• Molecular Weight: 191.293
• Mol File: 669008-25-7.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 259.008 °C at 760 mmHg
• Flash Point: 110.445 °C
• Appearance: /
• Density: 1.12 g/cm³
• Vapor Pressure: 0.013mmHg at 25°C
• Refractive Index: 1.492
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.01±0.20(Predicted)
• CAS DataBase Reference: 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE(669008-25-7)
• EPA Substance Registry System: 1-METHYL-CYCLOPROPANESULFONIC ACID TERT-BUTYLAMIDE(669008-25-7)

Safety Data

• Hazardous Substances Data: 669008-25-7(Hazardous Substances Data)

Usage

General Description

1-Methyl-cyclopropanesulfonic acid tert-butylamide is a chemical compound with the molecular formula C8H17NO2S. It is a sulfonamide compound, which is a class of organic chemicals containing a sulfonyl group (SO2) attached to an amino group. The tert-butylamide functional group in this compound consists of a tert-butyl group bonded to a nitrogen atom. This chemical is commonly used as a reagent and intermediate in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. It is also used as a strong base in various organic reactions and is known for its high stability and solubility in organic solvents.

InChI:InChI=1/C8H17NO2S/c1-7(2,3)9-12(10,11)8(4)5-6-8/h9H,5-6H2,1-4H3

Upstream product

• 630421-42-0 N-t-butyl-1-cyclopropylsulfonamide 
• 74-88-4 methyl iodide 
• 63132-85-4 N-tert-butyl-(3-chloro)propylsulfonamide 

Downstream Products

• 669008-26-8 1-methylcyclopropane-1-sulfonamide 

Relevant articles and documents

P2-quinazolinones and bis-macrocycles as new templates for next-generation hepatitis C virus NS3/4a protease inhibitors: Discovery of MK-2748 and MK-6325

With the goal of identifying inhibitors of hepatitis C virus (HCV) NS3/4a protease that are potent against a wide range of genotypes and clinically relevant mutant viruses, several subseries of macrocycles were investigated based on observations made during the discovery of MK-5172. Quinazolinone-containing macrocycles were identified as promising leads, and optimization for superior cross-genotype and mutant enzyme potency as well as rat liver and plasma concentrations following oral dosing, led to the development of MK-2748. Additional investigation of a series of bis-macrocycles containing a fused 18- and 15-membered ring system were also optimized for the same properties, leading to the discovery of MK-6325. Both compounds display the broad genotype and mutant potency necessary for clinical development as next-generation HCV NS3/4a protease inhibitors.

Novel Compound for the Treatment of Hepatitis C

The present invention provides (1aR,12bS)-8-cyclohexyl-11-fluoro-N-((1-methylcyclopropyl)sulfonyl)-1a-((3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl)carbonyl)-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide (formula I), including pharmaceutically acceptable salts, as well as compositions and methods of using the compound. The compound has activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

HEPATITIS C VIRUS INHIBITORS

Hepatitis C virus inhibitors having the general formula are disclosed. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.