669066-91-5

Basic information

• Product Name: 5-BROMO-3-FLUOROPICOLINIC ACID
• Synonyms: 5-BROMO-3-FLUOROPICOLINIC ACID;5-BROMO-3-FLUOROPYRIDINE-2-CARBOXYLIC ACID;5-Bromo-3-fluoro-2-pyridinecarboxylic acid;5-Bromo-3-fluoropicolinic acid, 5-Bromo-2-carboxy-3-fluoropyridine;5-Bromo-3-fluoropyridine-2-carboxylic acid 95%
• CAS NO: 669066-91-5
• Molecular Formula: C₆H₃BrFNO₂
• Molecular Weight: 220
• Mol File: 669066-91-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 175-180℃
• Boiling Point: 290.5±40.0 °C(Predicted)
• Appearance: /
• Density: 1.903±0.06 g/cm3(Predicted)
• Refractive Index: 1.589
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-3-FLUOROPICOLINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-3-FLUOROPICOLINIC ACID(669066-91-5)
• EPA Substance Registry System: 5-BROMO-3-FLUOROPICOLINIC ACID(669066-91-5)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 669066-91-5(Hazardous Substances Data)

Usage

General Description

5-Bromo-3-Fluoropicolinic Acid is a specialized chemical compound often used in various scientific and industrial contexts. 5-BROMO-3-FLUOROPICOLINIC ACID’s molecular formula is C6H3BrFNO2, and it features both bromine and fluorine as part of its structure. It is also known by its other name, 2-Bromo-6-fluoro-3-pyridinecaroxylic acid. Its usage, like many chemical compounds, is highly dependent upon the specifics of the industry or study it is involved in. In terms of handling and safety, it's important to consider potential risks or toxicity and to adhere to all safety guidelines and requirements for this chemical. It should be stored in a cool, dry place away from heat and ignition sources.

InChI:InChI=1/C6H3BrFNO2/c7-3-1-4(8)5(6(10)11)9-2-3/h1-2H,(H,10,11)

Upstream product

• 15862-34-7 5-bromo-3-nitro-2-pyridone 
• 886373-28-0 5-bromo-3-fluoropyridine-2-carbonitrile 
• 573675-25-9 5-bromo-3-nitropyridine-2-carbonitrile 
• 15862-37-0 2,5-dibromo-3-nitro-pyridine 
• 669066-89-1 3-amino-5-bromopyridine-2-carboxylic acid amide 
• 669066-90-4 5-bromo-3-fluoro-pyridine-2-carboxylic acid amide 

Downstream Products

• 1211538-72-5 methyl 5-bromo-3-fluoro-pyridine-2-carboxylate 
• 1206968-92-4 (5-bromo-3-fluoropyridin-2-yl)methanol 
• 1256836-96-0 methyl 3-fluoro-5-hydroxypyridine-2-carboxylate 
• 1334405-60-5 ethyl 3-amino-5-bromopyridine-2-carboxylate 

Relevant articles and documents

HETEROCYLIC COMPOUNDS

The present invention aims to provide a heterocyclic compound having an AMPA receptor potentiator effect, which is expected to be useful as an agent for the prophylaxis or treatment of depression, Alzheimer's disease, schizophrenia, attention deficit hyperactivity disorder (ADHD) and the like. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof.

SMALL MOLECULE BRADYKININ B1 RECEPTOR ANTAGONISTS

Disclosed are compounds of formula (I) which are bradykinin B1 receptor (B1R) antagonists. These compounds are useful to treat diseases or relieve adverse symptoms associated with inflammation and pain. The invention encompasses novel compounds and acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases involving inflammation and pain.

ALPHA-HYDROXY AMIDES AS BRADYKININ ANTAGONISTS OR INVERSE AGONISTS

α-Hydroxy amide derivatives of the general formula (I) are bradykinin B1 antagonists or inverse agonists useful in the treatment or prevention of symptoms such as pain and inflammation associated with the bradykinin B1 pathway. R2a is selected from (1) a group selected from Ra. (2) (CH2)nNRbC(O)Ra. (3)(CH2)nNRbSO2Rd.(4)(CH2)nNRbCO2Ra.(5)(CH2)k-heterocycle optionally substituted with 1 to 3 groups independently selected from halogen.nitro, cyano.ORa.SRa.C1-4 alkyl and C1-3 haloakyl wherein said heterocycle is (a) a 5-membered heteroaromatic ring having a ring heteroatom selected from N.O and S. and optionally having up to 3 additional ring nitrogen atoms wherein said ring is optionally benzo-fused; or(b) a 6-membered heteromatic ring containing from 1 to 3 ring nitrogen atoms and N-oxydes thereof. Wherein said ring is optionally benzo-fused. (6)(CH2)kCO2Ra.and (7)(CH2)C(O)NRbRc. R2b is OH or a group selected from R2a; or R2a and R2b together with the carbon atom to which they are attached form a 3-to 7-membered carbocyclic ring optionally substituted with 1 to 4 groups independently selected from halogen. ORa. C1-4 alkyl and C1-4 haloalkyl;