66933-51-5

Basic information

• Product Name: 4-morpholin-4-yl-pyridine-2-carboxylic acid 4-methyl-anilide
• CAS NO: 66933-51-5
• Molecular Weight: 297.357
• Mol File: 66933-51-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-morpholin-4-yl-pyridine-2-carboxylic acid 4-methyl-anilide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-morpholin-4-yl-pyridine-2-carboxylic acid 4-methyl-anilide(66933-51-5)
• EPA Substance Registry System: 4-morpholin-4-yl-pyridine-2-carboxylic acid 4-methyl-anilide(66933-51-5)

Safety Data

• Hazardous Substances Data: 66933-51-5(Hazardous Substances Data)

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 106-49-0 p-toluidine 
• 82776-75-8 N-Cyclopentyl-N-(4-morpholin-4-yl-pyridine-2-carbonyl)-benzamide 
• 66933-68-4 4-morpholin-4-yl-pyridine-2-carboxylic acid 

Relevant articles and documents

Potential Acyl-transfer Agents. Reactions of N-Acyl-2-pyridinecarboxamides with Nucleophiles

A fast reaction is obserwed between a series of N-acyl-2-pyridinecarboxamides and cyclopentylamine or pyrrolidine.Most of the acylamides react exclusively at the pyridine-2-carbonyl group.The selectivity of these reactions is explained by the reaction of the pyridine-nitrogen as a base towards the external nucleophile in a five-ring transition state.The acylamides undergo slow reactions with 4-methylaniline, methanol or water.Several reaction paths are observed with these less reactive nucleophiles.An intramolecular acyl group transfer prior to the reaction with an external nucleophile is indicated for three of the N-acylamides which have an N,N-dialkylamino substituent in the pyridine-4-position.Nucleophilic attack occurs predominantly at the N-acyl group of these three compounds which are moderately active acyl-transfer agents.