66966-19-6

Basic information

• Product Name: (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE
• Synonyms: (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE;R-Allyl glycidyl catechol
• CAS NO: 66966-19-6
• Molecular Formula: C12H14O3
• Molecular Weight: 206.24
• Mol File: 66966-19-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 305.1±17.0 °C(Predicted)
• Appearance: /
• Density: 1.109±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE(66966-19-6)
• EPA Substance Registry System: (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE(66966-19-6)

Safety Data

• Hazardous Substances Data: 66966-19-6(Hazardous Substances Data)

Usage

Description

(2R)-3-(O-allyloxphenoxy)-1,2-epoxypropane is an epoxy compound characterized by a molecular structure that includes an epoxide group and an allyloxy group attached to a phenoxy group. As a chiral molecule, it has a specific stereochemistry denoted as (2R)-3-. (2R)-3-(O-ALLYLOXYPHENOXY)-1,2-EPOXYPROPANE is recognized for its reactivity and versatility, stemming from the presence of the epoxide group, and is further enhanced by the additional functionality and reactivity provided by the allyloxy group. These features make it a valuable building block in organic synthesis and suitable for a wide range of chemical transformations and applications across various industries.

Uses

Used in Chemical Synthesis:
(2R)-3-(O-allyloxphenoxy)-1,2-epoxypropane is utilized as a key intermediate in the synthesis of various chemical products due to its reactivity and the presence of the epoxide and allyloxy groups. This allows for the creation of a broad spectrum of compounds, including polymers, resins, and pharmaceuticals, which are essential in multiple industries.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, (2R)-3-(O-allyloxphenoxy)-1,2-epoxypropane serves as a crucial building block for the development of new drugs. Its unique structure and reactivity enable the synthesis of complex molecules with potential therapeutic applications.
Used in Polymer and Resin Production:
(2R)-3-(O-allyloxphenoxy)-1,2-epoxypropane is employed as a reactive monomer in the production of polymers and resins. Its incorporation into these materials can enhance properties such as strength, flexibility, and chemical resistance, making them suitable for a variety of applications, including coatings, adhesives, and composite materials.
Used in Industrial Applications:
Across different industries, (2R)-3-(O-allyloxphenoxy)-1,2-epoxypropane is used for its versatility and reactivity in chemical transformations. This allows for the development of innovative products and processes that can improve efficiency, performance, and sustainability in various sectors.

Upstream product

• 106-89-8 epichlorohydrin 
• 1126-20-1 2-allyloxyphenol 
• 118712-54-2 glycidyl p-toluenesulfonate 
• 120-80-9 benzene-1,2-diol 
• 141987-51-1 (R)-3-(2-allyloxy phenoxy)-1-chloro-2-propanol 
• 70987-78-9 (S)-Glycidyl tosylate 
• 118712-60-0 S-oxiran-2-ylmethyl 4-nitrobenzenesulfonate 
• 115314-14-2 (2s)-(+)-glycidyl 3-nitrobenzenesulfonate 
• 6452-74-0 3-(o-Allyloxyphenoxy)-2-hydroxy-1-chlorpropan 
• 141987-34-0 Acetic acid 2-(2-allyloxy-phenoxy)-1-chloromethyl-ethyl ester 
• 51594-55-9 (R)-(-)-epichlorohydrin 
• 429-41-4 tetrabutyl ammonium fluoride 
• 115314-14-2 (R)-glycidyl nosylate 
• 6452-72-8 1-(2-allyloxyphenoxy)-2,3-epoxypropane 

Downstream Products

• 66825-06-7 1-(2-Allyloxy-phenoxy)-3-(2-amino-ethylamino)-propan-2-ol 
• 53672-27-8 N-{2-[3-(2-Allyloxy-phenoxy)-2-hydroxy-propylamino]-ethyl}-isobutyramide 
• 59613-89-7 1-(2-Allyloxy-phenoxy)-3-{6-[3-(2-allyloxy-phenoxy)-2-hydroxy-propylamino]-hexylamino}-propan-2-ol 
• 66817-28-5 N-({2-[3-(2-Allyloxy-phenoxy)-2-hydroxy-propylamino]-ethylcarbamoyl}-methyl)-4-chloro-benzamide 
• 66901-82-4 (R)-2-allyloxy-1-(2,3-dihydroxypropoxy)benzene 

Relevant articles and documents

A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors

Microtuning of the enzyme active pocket has led to a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots. This study represents a breakthrough in protein engineering of epoxide hydrolases and resulted in enhanced activity toward bulky substrates. Hot pockets: Microtuning of the enzyme active pocket gives a smart library of epoxide hydrolase variants with an expanded substrate spectrum covering a series of typical β-blocker precursors. Improved activities of 6- to 430-fold were achieved by redesigning the active site at two predicted hot spots, and enhanced activity toward bulky substrates was found.

Propanolamine derivatives

This invention relates to new propanolamine derivatives presented by the following formula [I]: wherein R1 is hydrogen or lower alkenyloxy, R2 is carboxy(lower)alkoxy or protected carboxy(lower)alkoxy, R3 is hydrogen or N-protective group, n is an integer of 1 or 2, and salts thereof which have gut selective sympathomimetic, anti-ulcerous, anti-pancreatitis, lipolytic and anti-pollakisuria activities, to processes for the preparation thereof and to a pharmaceutical composition comprising the same.

Process for the preparation of 3-amino-2-hydroxy-1-propyl ethers

PCT No. PCT/JP97/03220 Sec. 371 Date Apr. 28, 1999 Sec. 102(e) Date Apr. 28, 1999 PCT Filed Sep. 12, 1997 PCT Pub. No. WO98/12171 PCT Pub. Date Mar. 26, 1998A process for preparation of 3-amino-2-hydroxy-1-propyl ether of the formula wherein R1 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclic ring, R2 and R3 are the same or different hydrogen atom, a substituted or unsubstituted alkyl, or may form a ring together with an adjacent nitrogen atom, which ring may be interrupted with nitrogen atom, oxygen atom or sulfur atom, which is characterized in reacting an epoxy compound of the formula wherein X is halogen, in the presence of a fluoride salt, with an alcohol and then reacting an amine. According to the above method, an intermediates for synthesis of medicines is obtained in good yield and highly optical purity.