66967-25-7

Basic information

• Product Name: 2H-Pyran, 2-(3,4-dimethoxyphenoxy)tetrahydro-
• CAS NO: 66967-25-7
• Molecular Formula: C13H18O4
• Molecular Weight: 238.284
• Mol File: 66967-25-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, 2-(3,4-dimethoxyphenoxy)tetrahydro-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, 2-(3,4-dimethoxyphenoxy)tetrahydro-(66967-25-7)
• EPA Substance Registry System: 2H-Pyran, 2-(3,4-dimethoxyphenoxy)tetrahydro-(66967-25-7)

Safety Data

• Hazardous Substances Data: 66967-25-7(Hazardous Substances Data)

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 2033-89-8 3,4-dimethoxyphenol 

Downstream Products

• 65162-28-9 6-hydroxy-2,3-dimethoxybenzaldehyde 
• 192123-81-2 2-(4-acetoxymethyl-pent-4-enyl)-3,4-dimethoxyphenoxytetrahydropyran 
• 192123-98-1 2-(4-acetoxymethylpent-4-enyl)-3,4,4-trimethoxycyclohexa-2,5-dienone 
• 192124-77-9 2-(4-hydroxymethyl-pent-4-enyl)-3,4-dimethoxyphenoxytetrahydropyran 
• 192124-76-8 3,4-dimethoxy-2-(4-methyl-4-oxyranylpentane)phenoxytetrahydropyran 
• 192124-80-4 Acetic acid 5-(6-hydroxy-2,3-dimethoxy-phenyl)-2-methylene-pentyl ester 
• 192124-01-9 3,4,4-trimethoxy-2-(3,3-dimethylpent-4-enyl)cyclohexa-2,5-dienone 
• 192123-95-8 3,4,4-trimethoxy-2-(4-methyl-pent-4-enyl)cyclohexa-2,5-dienone 
• 192123-92-5 3,4,4-trimethoxy-2-(hex-5-enyl)cyclohexa-2,5-dienone 
• 192123-66-3 3,4,4-trimethoxy-2-(pent-4-enyl)cyclohexa-2,5-dienone 
• 192124-81-5 2-(3,3-Dimethyl-pent-4-enyl)-3,4-dimethoxy-phenol 
• 192124-75-7 3,4-Dimethoxy-2-(4-methyl-pent-4-enyl)-phenol 
• 192124-72-4 2-Hex-5-enyl-3,4-dimethoxy-phenol 
• 192124-67-7 3,4-Dimethoxy-2-pent-4-enyl-phenol 

Relevant articles and documents

A Modular Synthesis of the Lamellarins: Total Synthesis of Lamellarin G Trimethyl Ether

A modular synthesis of the lamellarin family of natural products has been developed that is based on the application of three iterative halogenation/cross-coupling reaction sequences. The ability to halogenate the pyrrole core in a regioselective fashion, even in the presence of highly electron-rich aryl substituents, has been established. The compatibility of Suzuki coupling conditions with free alcohols and phenols in the boronic acids has been employed to reduce the number of protection/deprotection steps. Indeed, the presence of a free phenol on boronic acid 3 has been determined to be critical for the successful final coupling in route to lamellarin G trimethyl ether, since protected versions fail to undergo coupling.

Pharmaceutical compounds, preparation, use and intermediates therefor and their preparation

This invention is directed to novel ether compounds of formula (I) STR1 which are of value in medicine in the palliation of haemoglobinopathies, in particular sickle-cell anemia, and also in the palliation of pulmonary dyefunction, protection from the effects of hypoxia and the radio-sensitization of tumours. The invention is also directed to methods for the preparation of the ether compounds, to pharmaceutical formulations containing them, the preparation of such formulations and the use of the compounds in human medicine. Also provided by the invention are intermediates of value in the preparation of the ether compounds, by the methods described, and the preparation of the intermediates.