6698-26-6 Usage
Description
2',5'-DIDEOXYADENOSINE is a nucleoside analog that is structurally similar to adenosine but lacks the hydroxyl groups at the 2' and 5' positions of the sugar moiety. This modification results in unique biological properties and potential applications in various fields.
Uses
Used in Pharmaceutical Research:
2',5'-DIDEOXYADENOSINE is used as a research tool for elucidating the mechanism of action of certain compounds, such as diligustilide (DLG). Its unique structure allows for the investigation of molecular interactions and signaling pathways, contributing to a better understanding of drug action and potential therapeutic targets.
Used in Enzyme Inhibition:
2',5'-DIDEOXYADENOSINE is used as an inhibitor of adenylate cyclase (AC), an enzyme that plays a crucial role in cellular signaling by catalyzing the conversion of ATP to cyclic AMP (cAMP). By inhibiting AC, 2',5'-DIDEOXYADENOSINE can modulate cellular processes and potentially be utilized in the development of therapeutic agents targeting specific diseases or conditions.
Biochem/physiol Actions
Cell-permeable adenylyl cyclase inhibitor. IC50 = 2.7 μM in detergent-dispersed rat brain preparations.
Check Digit Verification of cas no
The CAS Registry Mumber 6698-26-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,9 and 8 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6698-26:
(6*6)+(5*6)+(4*9)+(3*8)+(2*2)+(1*6)=136
136 % 10 = 6
So 6698-26-6 is a valid CAS Registry Number.
6698-26-6Relevant articles and documents
Synthesis of 2',5'-dideoxy-adenosine-3'-monophosphate derivatives as allosteric inhibitors of adenylyl cyclase
Desaubry,Shoshani,Johnson
, p. 1453 - 1460 (2007/10/03)
The synthesis of a fluorescent and a lipophilic conjugate of 2',5'- dideoxy-3'AMP, an allosteric inhibitor of adenylyl cyclase, has been devised.
