6698-46-0 Usage
Description
5-O-Benzoyl-1,2-O-isopropylidene-alpha-D-erythro-pent-3-ulofuranose is a chemical compound that serves as a key intermediate in the synthesis of various biologically active molecules. It is characterized by the presence of a benzoyl group at the 5-O position and an isopropylidene protecting group at the 1,2-O positions, with the alpha-D-erythro-pent-3-ulose core structure.
Uses
Used in Pharmaceutical Industry:
5-O-Benzoyl-1,2-O-isopropylidene-alpha-D-erythro-pent-3-ulofuranose is used as a key intermediate in the chemical synthesis of D-ribose, an essential component of nucleic acids and various other biological molecules. Its role in the synthesis process is crucial for the production of pharmaceuticals and other healthcare products.
Used in Biochemistry Research:
5-O-Benzoyl-1,2-O-isopropylidene-alpha-D-erythro-pent-3-ulofuranose is also utilized in the preparation of methylated nucleoside derivatives, which are important for studying the structure and function of nucleic acids and their interactions with proteins. The synthesis of these derivatives contributes to a better understanding of molecular biology and the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 6698-46-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,6,9 and 8 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 6698-46:
(6*6)+(5*6)+(4*9)+(3*8)+(2*4)+(1*6)=140
140 % 10 = 0
So 6698-46-0 is a valid CAS Registry Number.
InChI:InChI=1/C15H16O6/c1-15(2)20-12-11(16)10(19-14(12)21-15)8-18-13(17)9-6-4-3-5-7-9/h3-7,10,12,14H,8H2,1-2H3
6698-46-0Relevant articles and documents
Stereoselective synthesis of new higher carbon sugars from D-xylose
Liu, Hong-Min,Zou, Da-Peng,Zhang, Fuyi,Zhu, Wei-Guo,Peng, Tao
, p. 2103 - 2106 (2004)
A simple, one-pot multi-step route for the synthesis of a higher carbon sugar 3 by the HDA reaction of a α,β-unsaturated ketone prepared in situ from protected D-xylose with PDC in C6H6 or CH 3CN, followed by the reduction
The Chiron Approach to (3 R,3 aS,6 aR)-Hexahydrofuro[2,3- b]furan-3-ol, a Key Subunit of HIV-1 Protease Inhibitor Drug, Darunavir
Ghosh, Arun K.,Markad, Shivaji B.,Robinson, William L.
, p. 1216 - 1222 (2020/12/22)
We describe an enantioselective synthesis of (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol which is a key subunit of darunavir, a widely used HIV-1 protease inhibitor drug for the treatment of HIV/AIDS patients. The synthesis was achieved in optically pure form utilizing commercially available sugar derivatives as the starting material. The key steps involve a highly stereoselective substrate-controlled hydrogenation, a Lewis acid catalyzed anomeric reduction of a 1,2-O-isopropylidene-protected glycofuranoside, and a Baeyer-Villiger oxidation of a tetrahydrofuranyl-2-aldehyde derivative. This optically active ligand alcohol was converted to darunavir efficiently.
SELECTIVE INHIBITORS OF PROTEIN ARGININE METHYLTRANSFERASE 5
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Paragraph 0248, (2020/10/20)
The disclosure is directed to methods of treating disease using compounds of Formula (I).