66985-17-9 Usage
Description
3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide monohydrate, also known as Ipratropium bromide monohydrate, is a quaternary ammonium compound with bronchodilator properties. It is a derivative of atropine and belongs to the class of anticholinergic agents. Ipratropium bromide monohydrate works by blocking the action of acetylcholine on muscarinic receptors, leading to the relaxation of bronchial smooth muscles and alleviating bronchoconstriction.
Uses
Used in Respiratory Applications:
Ipratropium bromide monohydrate is used as a bronchodilator for the treatment of chronic obstructive pulmonary disease (COPD), asthma, and other respiratory conditions characterized by bronchoconstriction. It helps to improve lung function and reduce symptoms such as shortness of breath, wheezing, and coughing.
Used in Pharmaceutical Industry:
Ipratropium bromide monohydrate is used as an active pharmaceutical ingredient in the formulation of various inhalation products, such as metered-dose inhalers and nebulizer solutions. These formulations are designed to deliver the drug directly to the lungs, ensuring optimal therapeutic effects with minimal systemic side effects.
Used in Research Applications:
Ipratropium bromide monohydrate is also used in research settings to study the effects of muscarinic receptor inhibition on various physiological processes, such as smooth muscle contraction, gland secretion, and neurotransmission. This helps in understanding the underlying mechanisms of action and potential therapeutic applications of anticholinergic agents.
Used in Veterinary Medicine:
Ipratropium bromide monohydrate is used in veterinary medicine for the treatment of respiratory conditions in animals, such as horses and dogs, that exhibit symptoms similar to those seen in humans with COPD or asthma. It helps to alleviate respiratory distress and improve the overall quality of life for these animals.
Biochem/physiol Actions
Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β2 adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways.
Clinical Use
Anticholinergic bronchodilator:
Reversible airways obstruction, particularly in
COPD
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
After inhalation, around 10-30% of a dose is deposited
in the lungs where it exerts its therapeutic effect. Only
a small amount of ipratropium reaches the systemic
circulation. The majority of a dose is swallowed but
is poorly absorbed from the gastrointestinal tract.
Ipratropium and its metabolites are eliminated in the
urine and faeces.
Check Digit Verification of cas no
The CAS Registry Mumber 66985-17-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,9,8 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 66985-17:
(7*6)+(6*6)+(5*9)+(4*8)+(3*5)+(2*1)+(1*7)=179
179 % 10 = 9
So 66985-17-9 is a valid CAS Registry Number.
InChI:InChI=1/C20H30NO3.BrH.H2O/c1-14(2)21(3)16-9-10-17(21)12-18(11-16)24-20(23)19(13-22)15-7-5-4-6-8-15;;/h4-8,14,16-19,22H,9-13H2,1-3H3;1H;1H2/q+1;;/p-1
