66996-92-7Relevant articles and documents
Studies on pyrazine derivatives: part X. Synthesis and tuberculostatic activity of some 6 cyclamino, 6-imidazolyl-and triazolylpyrazine-2- carboxylic acids derivatives
Foks,Janowiec,Pilarski
, p. 105 - 111,109, 110 (2007/10/08)
The 6(2'-methylpiperidine-, 2', 6'-dimethylmorpholino-, imidazolyl- and triazolyl)-2-cyanopyrazines were prepared from 2-cyano-6-chloropyrazine. The -CN group was then transformed into COOH, CONH2, CSNH2, CONHNH2, CONHOH and C(NOH)NH2 functions. All compounds obtained were of weak tuberculostatic activity. One compound was active against isoniazide, capreomycin and ethionamide resistant strains at the concentration range of 31.2-62.5 μg/cm3.