67-16-3 Usage
Description
Thiamine disulfide, also known as vitamin B1 disulfide, is a sulfur-containing derivative of thiamine (vitamin B1). It possesses antioxidant properties and has been studied for its potential health benefits and therapeutic applications.
Uses
Used in Pharmaceutical Industry:
Thiamine disulfide is used as an antioxidant for its ability to inhibit lipid peroxidation in rat liver microsomes and free radical oxidation of oleic acid in vitro. Its antioxidant properties make it a promising candidate for the development of pharmaceuticals targeting various health conditions related to oxidative stress.
Used in Antiviral Applications:
Thiamine disulfide has been explored as a potent inhibitor of HIV-1, demonstrating its potential use in antiviral therapies. Its ability to inhibit the replication and spread of the virus makes it a valuable compound for further research and development in the field of virology and infectious diseases.
Originator
Arcalion,Servier,France,1974
Manufacturing Process
20 parts by weight of thiamin are dissolved in 25 parts of water, a cold
solution of 5 parts by weight of caustic soda in 25 parts of water added and
the mixture oxidized with a solution of 2.4 parts by weight of caustic soda and
20 parts by weight of potassium ferric cyanide in 80 parts of water while
stirring in the cold. The liquid is then evaporated to dryness and the resulting
oxidation product extracted with warm butyl alcohol.The butyl-alcoholic solution is evaporated in vacuo and the residue dissolved
with gentle heating in 25 parts by volume of methyl alcohol. 100 parts by
volume of acetone are added, the solution filtered and further quantities of
acetone added, whereupon crystallization sets in. Yield: 12.2 parts by weight
of the pure product, having the melting point 177° to 179°C.
Therapeutic Function
Enzyme cofactor vitamin
Check Digit Verification of cas no
The CAS Registry Mumber 67-16-3 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 6 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 67-16:
(4*6)+(3*7)+(2*1)+(1*6)=53
53 % 10 = 3
So 67-16-3 is a valid CAS Registry Number.
InChI:InChI=1/C24H34N8O4S2/c1-15(31(13-35)11-19-9-27-17(3)29-23(19)25)21(5-7-33)37-38-22(6-8-34)16(2)32(14-36)12-20-10-28-18(4)30-24(20)26/h9-10,13-14,33-34H,5-8,11-12H2,1-4H3,(H2,25,27,29)(H2,26,28,30)/b21-15-,22-16-
