670253-37-9Relevant articles and documents
High-selectivity fibroblast growth factor receptor inhibitor and application
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Paragraph 0074-0078, (2021/07/08)
The invention discloses a high-selectivity fibroblast growth factor receptor inhibitor and application, and particularly relates to a compound shown in a formula (I) or a pharmaceutically acceptable salt, a solvate, a geometric isomer, a stereoisomer, a tautomer and any mixture thereof. The compound shown in the formula (I) or the pharmaceutically acceptable salt, the solvate and the pharmaceutical composition thereof can be applied to prevention or treatment of diseases related to FGFR4 activity or overexpression, and can also be combined with other medicines to be used for treating various related diseases, especially for treating various cancers, wherein the cancers may be liver cancer, lung cancer, gastric cancer, breast cancer, ovarian cancer, prostate cancer, renal cell carcinoma, skin cancer, colon cancer, bile duct cancer, glioma or sarcoma.
Novel crystal form product of urea compound, and preparation method thereof
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Paragraph 0033-0034; 0038, (2020/07/06)
The invention particularly relates to a novel crystal form of a urea compound, and a preparation method thereof. According to the method, an organic solvent crystallization solvent system is adopted,an free alkali and an acid are paired to form ion pairs, crystallization is conducted, and then heat preservation pulping crystallization is conducted within a certain temperature range to obtain thenovel crystal form, wherein the crystal form product is high in water solubility, simple in preparation method, high in yield, stable in property and easy to store, transport and use in the later period. The preparation method provided by the invention is good in process reproducibility, simple to operate and suitable for industrial production.
A class of intermediates for preparing anticancer drugs
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Paragraph 0057-0060, (2019/07/04)
The invention discloses a raw material for synthesizing an anticancer drug, and a key intermediate for synthesizing an anticancer drug. The invention further discloses a preparation method of an anticancer drug. According to the present invention, the syn