67036-15-1

Basic information

• Product Name: p-nitrophenylcarbonate hexyl ester
• Synonyms: p-nitrophenylcarbonate hexyl ester
• CAS NO: 67036-15-1
• Molecular Weight: 267.282
• Mol File: 67036-15-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: p-nitrophenylcarbonate hexyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: p-nitrophenylcarbonate hexyl ester(67036-15-1)
• EPA Substance Registry System: p-nitrophenylcarbonate hexyl ester(67036-15-1)

Safety Data

• Hazardous Substances Data: 67036-15-1(Hazardous Substances Data)

Upstream product

• 7693-46-1 4-Nitrophenyl chloroformate 
• 111-27-3 hexan-1-ol 
• 5070-13-3 bis-(p-nitrophenyl) carbonate 
• 100-02-7 4-nitro-phenol 
• 6092-54-2 n-hexyl chloroformate 

Downstream Products

• 211915-06-9 dabigatran etexilate 
• 211915-06-9 ethyl 3-(1-{2-[({4-[amino({[(hexyloxy)carbonyl]imino})methyl]phenyl}amino)methyl]-1-methyl-1H-1,3-benzodiazol-5-yl}-N-(pyridin-2-yl)formamido)propanoate 

Relevant articles and documents

Practical synthesis of N-alkyl-N-alkyloxycarbonylaminomethyl prodrug derivatives of acetaminophen, theophylline, and 6-mercaptopurine

We report a novel synthesis of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) prodrugs of acetaminophen, theophylline, and 6-mercaptopurine by alkylation of the corresponding drug molecule with N-alkyl-N- alkyloxycarbonylaminomethyl chlorides in good yield. Most of the alkylating agents were efficiently synthesized by chloromethylation of N-alkyl carbamic acid alkyl esters, which in turn were made from alkyl amines and alkyl chloroformates. In cases where the alkyl chloroformates were not available, synthesis of N-alkyl carbamic acid alkyl esters was accomplished by converting an alcohol to a chloroformate or to an activated acylating agent such as acyl imidazoles or p-nitrophenylcarbonate esters, followed by their reaction with alkyl amines. Copyright Taylor & Francis Group, LLC.

COMPOUNDS USEFUL IN HIV THERAPY

The invention relates to compounds of Formula (I), salts thereof, pharmaceutical compositions thereof, as well as methods of treating or preventing HIV in subjects.

A darbey adds the group ester preparation method

The invention relates to a preparation method of Dabigatran etexilate. In a preparation process, acyl chloride or anhydride is used for replacing N, N minute-Carbonyldiimidazole (CDI ) or palladium on activated carbon, which must be used and is expensive in the prior art, the cost is greatly lowered, and used materials are cheap and are easily available, the process is simple and feasible, aftertreatment steps are simplified, column chromatography purification is not needed in whole operation steps, so that the process of the whole preparation method is simplified, and industrialization is convenient to realize; when a compound with a formula 2 is compounded, a sodium amide and ammonium salt system is adopted, and generation of a mass of acid pickle is avoided, so the production is safe, the environment is not polluted, and the preparation process is convenient and easy; when a compound with a formula 1 is compounded, a stable-property compound with a formula 7 is adopted, great convenience is brought for production, and the yield of the Dabigatran etexilate is effectively improved; the total yield of the Dabigatran etexilate prepared by the method reaches 60 to 70 percent.