67036-44-6

Basic information

• Product Name: (5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER
• Synonyms: (5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER;(2S)-5-oxo-2-Pyrrolidineacetic acid Methyl ester;Methyl 2-(5-oxopyrrolidin-2-yl)acetate
• CAS NO: 67036-44-6
• Molecular Formula: C₇H₁₁NO₃
• Molecular Weight: 157.16714
• Mol File: 67036-44-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 63-65 °C(Solv: ethyl ether (60-29-7))
• Boiling Point: 311.3°C at 760 mmHg
• Flash Point: 142.1°C
• Appearance: /
• Density: 1.132g/cm³
• Vapor Pressure: 0.000567mmHg at 25°C
• Refractive Index: 1.454
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 15.45±0.40(Predicted)
• CAS DataBase Reference: (5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER(67036-44-6)
• EPA Substance Registry System: (5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER(67036-44-6)

Safety Data

• Hazardous Substances Data: 67036-44-6(Hazardous Substances Data)

Usage

Description

(5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER, a methyl ester derivative of 5-oxo-pyrrolidin-2-yl acetic acid, is an organic compound that falls under the category of alpha-keto acids and their derivatives. This chemical is characterized by its potential applications in various fields, including organic synthesis and pharmaceutical research, and may also hold promise for future medical applications.

Uses

Used in Organic Synthesis:
(5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with different properties and applications.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER serves as a valuable compound for the development of new drugs. Its potential medical applications are currently being explored, and it may contribute to the advancement of treatments for various health conditions.
Safety and Handling:
Due to its chemical nature, it is crucial to handle and store (5-OXO-PYRROLIDIN-2-YL)-ACETIC ACIDMETHYL ESTER with care, adhering to the appropriate safety protocols and guidelines to ensure the safety of both individuals and the environment.

InChI:InChI=1/C7H11NO3/c1-11-7(10)4-5-2-3-6(9)8-5/h5H,2-4H2,1H3,(H,8,9)

Upstream product

• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 936114-75-9 methyl (3aS,4S,9bS)-4-(3-azidopropyl)-2,3,3a,4,5,9b-hexahydro-1-(phenylmethyl)-1H-pyrrolo-[3,2-c]quinoline-8-carboxylate 
• 936114-98-6 1-benzyl-4-(3-methanesulfonyloxy-propyl)-5-trifluoroacetyl-2,3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinoline-8-carboxylic acid methyl ester 
• 936114-95-3 methyl (3aS,4S,9bS)-2,3,3a,4,5,9b-hexahydro-5-(3-oxobutanoyl)-1-(phenylmethyl)-5-(trifluoroacetyl)-1H-pyrrolo[3,2-c]quinoline-8-carboxylate 
• 936114-71-5 methyl (3aS,4S,9bS)-2,3,3a,4,5,9b-hexahydro-5-(3-oxobutanoyl)-1-(phenylmethyl)-1H-pyrrolo-[3,2-c]quinoline-8-carboxylate 
• 936114-66-8 (3aS,4S,9bS)-8-iodo-2,3,3a,4,5,9b-hexahydro-5-(3-oxobutanoyl)-1-(phenylmethyl)-1H-pyrrolo-[3,2-c]quinoline-4-propyl acetate 
• 936114-61-3 (3aS,4S,9bS)-8-iodo-2,3,3a,4,5,9b-hexahydro-1-(phenylmethyl)-1H-pyrrolo[3,2-c]quinoline-4-propanol 
• 143771-08-8 (S)-2-((E)-4-Oxo-hept-2-enyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 143771-09-9 (R)-2-(4-Oxo-heptyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 143771-07-7 benzyl (S)-2-(2-oxoethyl)pyrrolidine-1-carboxylate 
• 143771-06-6 (-)-(S)-2-(2-hydroxyethyl)pyrrolidine-1-carboxylic acid benzyl ester 
• 74046-07-4 (+)-Vigabatrin 
• 936114-10-2 methyl 5-nitro-2-[(5S)-5-{[(tert-butyl)dimethylsilyloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate 
• 936114-41-9 methyl 5-amino-2-[(5S)-5-{[(tert-butyl)dimethylsilyiloxyethyl]}-2-oxo-1-pyrrolidinyl]benzoate 
• 936114-46-4 methyl 5-iodo-2-[(5S)-5-(hydroxyethyl)-2-oxo-1-pyrrolidinyl]benzoate 

Relevant articles and documents

Total synthesis of (-)-martinellic acid

An enantioselective formal total synthesis of the pyrrolo[3,2-c]quinoline natural product martinellic acid has been achieved. The key steps involve a Pd-catalyzed aryl amidation reaction of a pyrroglutamate derivative, an intramolecular [3+2] azomethine ylide-alkene cycloaddition and a reductive ring opening reaction.