6704-25-2

Basic information

• Product Name: 1,3-bis(3,4-dimethoxyphenyl)propan-2-one
• CAS NO: 6704-25-2
• Molecular Formula: C₁₉H₂₂O₅
• Molecular Weight: 330.375
• Mol File: 6704-25-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 448.6°C at 760 mmHg
• Flash Point: 195.8°C
• Density: 1.129g/cm³
• Vapor Pressure: 3.06E-08mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 1,3-bis(3,4-dimethoxyphenyl)propan-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(3,4-dimethoxyphenyl)propan-2-one(6704-25-2)
• EPA Substance Registry System: 1,3-bis(3,4-dimethoxyphenyl)propan-2-one(6704-25-2)

Safety Data

• Hazardous Substances Data: 6704-25-2(Hazardous Substances Data)

Usage

Appearance

Yellow crystalline compound

Functional groups

a. Two ketone functional groups (diketone)
b. Methoxy groups (-OCH3) attached to the phenyl rings

Usage

a. Reagent in organic synthesis
b. Production of pharmaceuticals and fragrance compounds

Potential applications

a. Treatment of neurodegenerative disorders (e.g., Alzheimer's disease)
b. Inhibition of beta-amyloid fibril formation
c. Antioxidant properties
d. Anti-inflammatory properties

Structure

a. Propan-2-one backbone with two phenyl rings attached at positions 1 and 3
b. Each phenyl ring has a 3,4-dimethoxy substitution pattern

Solubility

Likely soluble in organic solvents such as ethanol, methanol, or acetone

Stability

Stable under normal conditions, but sensitive to heat, light, or strong acids/bases

Safety precautions

a. Use gloves and eye protection when handling
b. Store in a cool, dry, and well-ventilated area
c. Avoid inhalation, ingestion, or skin contact

Synthesis

Typically synthesized through the condensation of appropriate starting materials, such as aromatic aldehydes and ketones, followed by a series of reactions to introduce the desired functional groups.

Upstream product

• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 
• 55720-88-2 homoveratric anhydride 
• 57543-25-6 (3,4-dimethoxy-phenyl)-acetic acid ; lead (II)-salt 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 156775-29-0 C₁₉H₂₃NO₆ 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 70360-83-7 1,2-dimethoxy-4-(2-nitroethyl)benzene 

Downstream Products

• 57543-28-9 N-[2-(3,4-dimethoxy-phenyl)-1-veratryl-ethyl]-formamide 
• 57543-26-7 2-(3,4-dimethoxy-phenyl)-1-veratryl-ethylamine 
• 113795-89-4 1,5-bis-(3,4-dimethoxy-phenyl)-3,7-diaza-bicyclo[3.3.1]nonan-9-one 

Relevant articles and documents

Gas permeability of hexaphenylbenzene based polymers of intrinsic microporosity

The synthesis and characterization of a series of novel hexaphenylbenzene (HPB) based polymers of intrinsic microporosity (PIM-HPBs) containing methyl, bromine, and nitrile substituents are reported. The successful formation of thin films from these polymers allowed the evaluation of the influence of the substituents on intrinsic microporosity and gas permeability. Analysis by the time-lag method also yielded information about gas diffusion coefficients and, indirectly, the gas solubility. The gas permeability varies as a function of the polarity of the substituents and shows a significant increase after treatment of the samples with methanol, especially for films cast from THF as the solvent. This enhancement, which is mostly due to an increase in the diffusion coefficient, is only partially lost upon aging of the membranes for 5 months. Measurements at different feed pressures confirm the typical dual mode sorption behavior, with increasing diffusivity and decreasing permeability and solubility as a function of the feed pressure.

A two-step, one pot preparation of amines via acyl succinimides. Synthesis of the calcimimetic agents cinacalcet, NPS R-467, and NPS R-568

Abstract A method has been developed for the preparation of amines through a process of coupling acyl succinimides derived from commercially available carboxylic acids with amines to afford the corresponding amides. These amides are then reduced in situ with either diisobutylaluminum hydride or lithium aluminum hydride. The reaction tandem of the coupling reaction followed by the reduction affords the amine in fair to good yields after purification by flash chromatography. This one-pot, two reaction tandem process has been successfully applied to the synthesis of the calcimimetic agents cinacalcet, NPS R-467, and NPS R-568.

Synthesis, chemical transformation and antimicrobial activity of a novel class of nitroolefins: 1,3-diaryl-2-nitroprop-1-enes

The synthesis of novel, biologically active 1,3-diaryl-2- nitroprop-1-enes (4) is reported. The synthesis involves condensation between aromatic aldehydes (1) and β-aryl nitroethanes (3). The chemical transformation of the nitro group in diaryl nitropropenes to a carbonyl function has resulted in a new route to the synthesis of an α-hydroxy analog (7c) of a naturally occurring 3,3',4,4'-tetramethoxy chalcone. The antimicrobial activity of the 1,3-diaryl-2-nitroprop-1-enes (4a- j) was tested against three gram positive bacteria, two gram negative bacteria and two fungi. These compounds exhibited broad spectrum antimicrobial activity.