67068-24-0Relevant articles and documents
Copper-catalyzed β-trifluoromethylation of conjugated hydrazones
Prieto, Alexis,Jeamet, Emeric,Monteiro, Nuno,Bouyssi, Didier,Baudoin, Olivier
, p. 4770 - 4773 (2014)
The Cu-catalyzed direct β-trifluoromethylation of α,β-unsaturated aldehyde N,N-dibenzylhydrazones with Togni hypervalent iodine reagent is described. The reaction yields stereodefined CF3-alkenyl derivatives under mild conditions and is propose
Insertion of Nitriles into Zirconocene 1-aza-1,3-diene Complexes: Chemoselective Synthesis of N-H and N-Substituted Pyrroles
Yu, Shasha,Xiong, Meijun,Xie, Xin,Liu, Yuanhong
supporting information, p. 11596 - 11599 (2016/02/19)
The direct insertion of nitriles into zirconocene-1-aza-1,3-diene complexes provides an efficient, chemoselective, and controllable synthesis of N-H and N-substituted pyrroles upon acidic aqueous work-up. The outcome of the reaction (that is, the formatio
New phosphonate reagents for aldehyde homologation
Petroski, Richard J.
, p. 3841 - 3854 (2008/02/10)
New phosphonate reagents were developed for the two-carbon homologation of aldehydes to unbranched or methyl-branched unsaturated aldehydes. The phosphonate reagents, diethyl methylformylphosphonate dimethylhydrazone and diethyl ethylformyl-2-phosphonate dimethylhydrazone, contained a protected aldehyde group instead of the usual ester group. A homologation cycle entailed condensation of the reagent with the starting aldehyde, followed by removal of the dimethylhydrazone protective group with a biphasic mixture of 1 M HCl and petroleum ether. This robust two-step process worked with aliphatic, α,β-unsaturated and aromatic aldehydes. Isolated yields for the condensation step ranged from 77% to 89%, and yields for the deprotection step ranged from 81% to 96%. Copyright Taylor & Francis Group, LLC.
