6712-35-2

Basic information

• Product Name: α-Methyl-α-propargylbenzyl alcohol
• Synonyms: 1-Methyl-1-phenyl-3-butyne-1-ol;2-Phenyl-4-pentyn-2-ol;α-Methyl-α-propargylbenzyl alcohol
• CAS NO: 6712-35-2
• Molecular Formula: C₁₁H₁₂O
• Molecular Weight: 160.21
• Mol File: 6712-35-2.mol
• Article Data: 38

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α-Methyl-α-propargylbenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: α-Methyl-α-propargylbenzyl alcohol(6712-35-2)
• EPA Substance Registry System: α-Methyl-α-propargylbenzyl alcohol(6712-35-2)

Safety Data

• Hazardous Substances Data: 6712-35-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 34, p. 15, 1993 DOI: 10.1016/S0040-4039(00)60046-1

Upstream product

• 106-96-7 propargyl bromide 
• 98-86-2 acetophenone 
• 2936-44-9 allenyl iodide 
• 67448-60-6 1-methyl-1-phenyl-4-(trimethylsilyl)-3-butyn-1-ol 
• 624-65-7 2-propynyl chloride 
• 57186-58-0 2-allenyl-5,5-dimethyl-1,3,2-dioxaborinane 
• 865350-17-0 4,4,5,5-tetramethyl-2-(propa-1,2-dien-1-yl)-1,3,2-dioxaborolane 
• 1314099-29-0 B-allenyl-1,3,2-dioxaborolane 
• 75168-42-2 (1-phenylethyl) propargyl ether 
• 18295-60-8 propargyl magnesium bromide 
• 146432-19-1 B-allenyl-9-BBN 
• 463-49-0 1,2-propanediene 
• 18295-60-8 allenylmagnesium bromide 

Downstream Products

• 856-15-5 4-phenyl-pent-3c-en-2-one-(2,4-dinitro-phenylhydrazone) 
• 1431380-93-6 1-(5-hydroxy-5-phenylhexa-1,3-diyn-1-yl)cyclohexanol 
• 5768-10-5 1,4-bis(1-hydroxycyclohexyl)buta-1,3-diyne 
• 1644563-22-3 5,5-diphenyl-4-(trifluoromethyl)pent-4-en-2-one 
• 82101-33-5 2,5-diphenyl-4-pentyn-2-ol 
• 1395300-72-7 4-phenylpent-1-yn-4-yl allyl ether 
• 1395300-43-2 C₂₀H₂₄O₄ 
• 1395300-59-0 C₂₀H₂₄O₄ 
• 1395300-40-9 C₂₀H₂₄O₃ 
• 1395300-57-8 C₂₀H₂₄O₃ 
• 1395300-38-5 C₁₉H₂₁BrO₃ 
• 1395300-36-3 C₁₉H₂₂O₃ 
• 1395300-30-7 C₁₃H₁₈O₃ 
• 1395300-63-6 C₁₃H₁₈O₂⁽¹⁸⁾O 

Relevant articles and documents

One-Pot γ-Lactonization of Homopropargyl Alcohols via Intramolecular Ketene Trapping

A one-pot γ-lactonization of homopropargyl alcohols via an alkyne deprotonation/boronation/oxidation sequence has been developed. Oxidation of the generated alkynyl boronate affords the corresponding ketene intermediate, which is trapped by the adjacent hydroxy group to furnish the γ-lactone. We have optimized the conditions as well as examined the substrate scope and synthetic applications of this efficient one-pot lactonization.

One-pot, regioselective synthesis of homopropargyl alcohols using pro-pargyl bromide and carbonyl compound by the mg-mediated reaction under solvent-free conditions

The elimination of volatile organic solvents in organic synthesis is the most important goal in “Green” chemistry. We report a simple, efficient and facile method for the addition of progargyl bromide to carbonyl compounds using Mg metal as a mediator under solvent-free conditions which could regioselectively generate homopropargyl alcohols efficiently in good to excellent yields. The procedure has advantages such as short reaction time, operationally simple, excellent product yields, high regioselectivity and organic solvent-free.

A Mechanochemical Zinc-Mediated Barbier-Type Allylation Reaction under Ball-Milling Conditions

A ball-milling-enabled zinc-mediated Barbier-type allylation reaction is reported. Notably, running the reaction in this manner renders it effective irrespective of the initial morphology of the zinc metal. The process is operationally simple, does not re