67120-39-2

Basic information

• Product Name: 1H-INDEN-1-AMINE, 5-CHLORO-2,3-DIHYDRO-
• Synonyms: 5-CHLORO-INDAN-1-YLAMINE;1H-INDEN-1-AMINE, 5-CHLORO-2,3-DIHYDRO-;5-Chloro-1-indanylamine;1-AMino-5-chloroindane;5-Chloroindan-1-aMine;5-chloro-2,3-dihydro-1H-inden-1-amine HCl
• CAS NO: 67120-39-2
• Molecular Formula: C₉H₁₀ClN
• Molecular Weight: 167.64
• Mol File: 67120-39-2.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 262.968 °C at 760 mmHg
• Flash Point: 112.839 °C
• Appearance: /
• Density: 1.214 g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.595
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.00±0.20(Predicted)
• CAS DataBase Reference: 1H-INDEN-1-AMINE, 5-CHLORO-2,3-DIHYDRO-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDEN-1-AMINE, 5-CHLORO-2,3-DIHYDRO-(67120-39-2)
• EPA Substance Registry System: 1H-INDEN-1-AMINE, 5-CHLORO-2,3-DIHYDRO-(67120-39-2)

Safety Data

• Hazardous Substances Data: 67120-39-2(Hazardous Substances Data)

Usage

General Description

1H-inden-1-amine, 5-chloro-2,3-dihydro- is a chemical compound with the molecular formula C9H9ClN. It is a white to light yellow solid substance and is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The presence of a chlorine atom on the 5th position of the indenyl ring gives this compound unique properties that make it useful in various industrial and research applications. It is important to handle this chemical with care and follow proper safety protocols as it can be harmful if it comes into contact with the skin, eyes, or if inhaled.

InChI:InChI=1/C9H10ClN/c10-7-2-3-8-6(5-7)1-4-9(8)11/h2-3,5,9H,1,4,11H2

Upstream product

• 90537-19-2 5-chloro-1-indanone oxime 
• 42348-86-7 5-chloro-1-indanone 

Relevant articles and documents

Deconstructive Oxygenation of Unstrained Cycloalkanamines

A deconstructive oxygenation of unstrained primary cycloalkanamines has been developed for the first time using an auto-oxidative aromatization promoted C(sp3)?C(sp3) bond cleavage strategy. This metal-free method involves the substitution reaction of cycloalkanamines with hydrazonyl chlorides and subsequent auto-oxidative annulation to in situ generate pre-aromatics, followed by N-radical-promoted ring-opening and further oxygenation by 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and m-cholorperoxybenzoic acid (mCPBA). Consequently, a series of 1,2,4-triazole-containing acyclic carbonyl compounds were efficiently produced. This protocol features a one-pot operation, mild reaction conditions, high regioselectivity and ring-opening efficiency, broad substrate scope, and is compatible with alkaloids, osamines, and peptides, as well as steroids.

HETEROCYCLIC AMIDE DERIVATIVES AS P2X7 RECEPTOR ANTAGONISTS

The invention relates to heterocyclic amide derivatives of formula (I), wherein R1, R2, R3, X and n are as defined in the description, their preparation and their use as pharmaceutically active compounds.

(FUSED RING ARYLAMINO AND HETEROCYCLYLAMINO) PYRIMIDYNYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES

Provided herein are (fused ring arylamino and heterocyclylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, e.g., a compound of Formula (I), and their pharmaceutical compositions, preparation, and use as agents or drugs for treating proliferative diseases.