67145-02-2

Basic information

• Product Name: Thymidine, 5,6-dihydro-5-hydroxy-, (S)-
• CAS NO: 67145-02-2
• Molecular Formula: C10H16N2O6
• Molecular Weight: 260.247
• Mol File: 67145-02-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Thymidine, 5,6-dihydro-5-hydroxy-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5,6-dihydro-5-hydroxy-, (S)-(67145-02-2)
• EPA Substance Registry System: Thymidine, 5,6-dihydro-5-hydroxy-, (S)-(67145-02-2)

Safety Data

• Hazardous Substances Data: 67145-02-2(Hazardous Substances Data)

Upstream product

• 50-89-5 thymidine 
• 145260-01-1 3-Trifluoromethyl-benzoic acid 3-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5-hydroxy-5-methyl-2,6-dioxo-hexahydro-pyrimidin-4-yl ester 
• 145260-00-0 1-[(2R,4S,5R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-5,6-dihydroxy-5-methyl-dihydro-pyrimidine-2,4-dione 
• 40733-26-4 3',5'-O-di(tert-butyldimethylsilyl)thymidine 
• 151936-96-8 (5R)-3',5'-Bis-O-(tert-butyldimethylsilyl)-5,6-dihydro-5-hydroxythymidine 
• 145260-02-2 3-Trifluoromethyl-benzoic acid 5-hydroxy-3-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-methyl-2,6-dioxo-hexahydro-pyrimidin-4-yl ester 

Downstream Products

• 1374759-51-9 5'-benzoyl-5,6-dihydro-5-hydroxy-thymidine 

Relevant articles and documents

Sonochemical transformation of thymidine: A mass spectrometric study

Abstract Ultrasound is extensively used in medical field for a number of applications including targeted killing of cancer cells. DNA is one of the most susceptible entities in any kind of free radical induced reactions in living systems. In the present work, the transformation of thymidine (dT) induced by ultrasound (US) was investigated using high resolution mass spectrometry (LC-Q-ToF-MS). dT was subjected to sonolysis under four different frequencies (200, 350, 620 and 1000 kHz) and at three power densities (10.5, 24.5 and 42 W/mL) in aerated as well as argon saturated conditions. A total of twenty modified nucleosides including non-fully characterized dT dimeric compounds were detected by LC-Q-ToF-MS. Out of these products, seven were obtained only in the argon atmosphere and two only in the aerated conditions. Among the identified products, there were base modified products and sugar modified products. The products were formed by the reaction of hydroxyl radical and hydrogen atom. Under aerated conditions, the reactions proceed via the formation of hydroperoxides, while in argon atmosphere disproportionation and radical recombinations predominate. The study provides a complete picture of sonochemical transformation pathways of dT which has relevance in DNA damage under ultrasound exposure.

Site-specific incorporation of the alkaline labile, oxidative stress product (5R)-5,6-dihydro-5-hydroxythymidine in an oligonucleotide

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Independent Generation of the Major Adduct of Hydroxyl Radical and Thymidine. Examination of Intramolecular Hydrogen Atom Transfer in Competition With Thiol Trapping.

5,6-Dihydro-5-hydroxythymid-6-yl (1) has been generated from 2 via photoinduced electron transfer from N-methylcarbazole.In agreement with prior reports, deuterium incorporation in conjunction with (2)H NMR analysis of 5,6-dihydro-5-hydroxythymidine (3) f