671809-10-2 Usage
Description
(3R,4R,6R)-5-AZIDO-2-AZIDOMETHYL-6-((1S,2S,4S)-4,6-DIAZIDO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL is a complex chemical compound featuring a tetrahydropyran ring with multiple azide and hydroxyl functional groups. This molecule is characterized by its eight azide groups, which confer high reactivity, making it a candidate for various chemical reactions and transformations. Its intricate structure and reactive nature suggest potential applications in fields such as chemical synthesis, materials science, and medicinal chemistry research. However, the complexity of the molecule and the associated safety concerns due to its reactivity necessitate careful handling and stringent safety protocols during its use.
Uses
Used in Chemical Synthesis:
(3R,4R,6R)-5-AZIDO-2-AZIDOMETHYL-6-((1S,2S,4S)-4,6-DIAZIDO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL serves as a reactive intermediate for chemical synthesis, particularly in the creation of new compounds through its azide groups. The reactivity allows for a wide range of chemical transformations, making it valuable for the development of novel molecules with specific properties.
Used in Materials Science:
In the field of materials science, (3R,4R,6R)-5-AZIDO-2-AZIDOMETHYL-6-((1S,2S,4S)-4,6-DIAZIDO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL can be utilized to develop new materials with unique characteristics. (3R,4R,6R)-5-AZIDO-2-AZIDOMETHYL-6-((1S,2S,4S)-4,6-DIAZIDO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL's reactivity and functional groups can be leveraged to create materials with tailored properties for specific applications.
Used in Medicinal Chemistry Research:
(3R,4R,6R)-5-AZIDO-2-AZIDOMETHYL-6-((1S,2S,4S)-4,6-DIAZIDO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL holds promise in medicinal chemistry research for the design and synthesis of new pharmaceutical agents. Its reactive azide groups can be used to create bioactive molecules with potential therapeutic applications.
Used in Safety and Handling Protocols Development:
Due to the compound's high reactivity and potential safety concerns, (3R,4R,6R)-5-AZIDO-2-AZIDOMETHYL-6-((1S,2S,4S)-4,6-DIAZIDO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL is also used in the development of safety and handling protocols. Establishing proper procedures for its use ensures the safety of researchers and the integrity of experiments involving this compound.
Check Digit Verification of cas no
The CAS Registry Mumber 671809-10-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,7,1,8,0 and 9 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 671809-10:
(8*6)+(7*7)+(6*1)+(5*8)+(4*0)+(3*9)+(2*1)+(1*0)=172
172 % 10 = 2
So 671809-10-2 is a valid CAS Registry Number.
671809-10-2Relevant articles and documents
An alternative and facile synthetic approach for the precursors of 3- and 6-aminosugar donors and study of one-pot glycosyltrasferation
Pandey, Uddav,Prasad Subedi, Yagya,Alfindee, Madher N.,Shepherd, Taylor,Tom Chang, Cheng-Wei
supporting information, p. 99 - 102 (2020/01/03)
3- and 6-aminosugars are common motifs in bioactive compounds playing pivotal roles in the bioactivity of the core molecules to which they are attached. However, de novo synthesis of 3- and 6-aminosugars and their corresponding glycosyl donors can be time
Neamine and 2-deoxystreptamine neomycin derivatives exhibit antinociceptive activity in rat models of phasic, incision and neuropathic pain
Prado, Wiliam A.,Rossaneis, Ana C.,Carvalho, Ivone,Zamoner, Luis Otvio B.,Corrado, Alexandre P.
, p. 1696 - 1704 (2016/01/26)
Objectives To assess the antinociceptive activity of the neomycin derivatives neamine and 2-deoxystreptamine following intraspinal administration in rats. Methods We used the tail-flick test and measured the threshold to mechanical stimulation in models of incisional and neuropathic pain. Key findings The derivatives produced antinociception in the tail-flick test and reduced mechanical allodynia in models of incisional and neuropathic pain. The approximate ED50 in milligrams (confidence limits in parenthesis) in these tests were 1.35 mg (0.61; 2.95), 0.20 mg (0.14; 0.27) and 0.28 mg (0.12; 0.63) for neamine, and 1.05 mg (0.68; 1.60), 0.78 mg (0.776; 0.783) and 0.79 mg (0.46; 1.34) for 2-deoxystreptamine, respectively. Neamine was more potent than 2-deoxystreptamine in the incisional and neuropathic pain models, but they had similar potency in the tail-flick test. Tetra-azidoneamine, a neamine derivative in which free amino groups are replaced with azido groups, did not change the incisional mechanical allodynia. The reduction of incisional allodynia by neamine and 2-deoxystreptamine was transitorily antagonized by intrathecal administration of calcium chloride. Conclusions The intraspinal administration of neamine and 2-deoxystreptamine is antinociceptive in rats. The presence of amino groups in the structure of these derivatives is fundamental to their antinociceptive effect, which may be due to a calcium antagonist activity.
An efficient and general route to the synthesis of novel aminoglycosides for RNA binding
Santana, Andrés G.,Bastida, ágatha,Del Campo, Teresa Martínez,Asensio, Juan Luis,Revuelta, Julia
supporting information; experimental part, p. 219 - 222 (2011/03/20)
An alternative and straightforward method to prepare aminoglycoside dimers and heterodimeric conjugates is reported. The novel type of modification may provide a promising way for the development of new ligands effectively targeting to RNA. Georg Thieme V
