672-75-3

Basic information

• Product Name: 3-BROMO-4-FLUOROBENZOYL CHLORIDE
• Synonyms: 3-BROMO-4-FLUOROBENZOYL CHLORIDE
• CAS NO: 672-75-3
• Molecular Formula: C₇H₃BrClFO
• Molecular Weight: 237.45
• EINECS: 211-596-9
• Product Categories: Fluorine series
• Mol File: 672-75-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 43-45 °C
• Boiling Point: 241.9 °C at 760 mmHg
• Flash Point: 100.1 °C
• Appearance: /
• Density: 1.742 g/cm³
• Vapor Pressure: 0.0351mmHg at 25°C
• Refractive Index: 1.561
• CAS DataBase Reference: 3-BROMO-4-FLUOROBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-4-FLUOROBENZOYL CHLORIDE(672-75-3)
• EPA Substance Registry System: 3-BROMO-4-FLUOROBENZOYL CHLORIDE(672-75-3)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 3265
• Hazardous Substances Data: 672-75-3(Hazardous Substances Data)

Usage

General Description

3-Bromo-4-Fluorobenzoyl chloride is an organic compound with the chemical formula C7H3BrFClO. It is a benzoyl chloride derivative, which means it contains a benzene ring with a carbonyl group attached to it. 3-BROMO-4-FLUOROBENZOYL CHLORIDE is used in organic synthesis as a building block for the production of pharmaceuticals, agrochemicals, and other organic compounds. It is a reactive and corrosive compound that should be handled with care, and is typically used in a controlled laboratory setting.

InChI:InChI=1/C7H3BrClFO/c8-5-3-4(7(9)11)1-2-6(5)10/h1-3H

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 13194-71-3 2-bromo-4-methyl-aniline; hydrochloride 
• 452-62-0 3-bromo-4-fluorotoluene 
• 1007-16-5 3-bromo-4-fluorobenzoic acid 

Downstream Products

• 1146733-54-1 6-(3-bromo-4-fluoro-benzoyl)-3,4-dimethyl-3H-benzoxazol-2-one 
• 1146733-55-2 6-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one 
• 1227162-78-8 2-(3-Bromo-4-fluoro-benzoyl)-6-fluoro-benzonitrile 
• 1226799-75-2 3-(3-bromo-4-fluoro-benzoyl)-pyridine-2-carbonitrile 
• 1174731-61-3 3-bromo-4-fluoro-N-(trimethylsilylmethyl)benzamide 
• 882670-70-4 3-bromo-4-fluoro-N-(2-fluoro-3-(trifluoromethyl)phenyl)benzamide 
• 1000201-15-9 2-(3-bromo-4-fluorobenzoyl)benzonitrile 

Relevant articles and documents

Structure-Activity Relationship of Phenylpyrazolones against Trypanosoma cruzi

Chagas disease is a neglected parasitic disease caused by the parasitic protozoan Trypanosoma cruzi and currently affects around 8 million people. Previously, 2-isopropyl-5-(4-methoxy-3-(pyridin-3-yl)phenyl)-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one (NPD-0227) was discovered to be a sub-micromolar inhibitor (pIC50=6.4) of T. cruzi. So far, SAR investigations of this scaffold have focused on the alkoxy substituent, the pyrazolone nitrogen substituent and the aromatic substituent of the core phenylpyrazolone. In this study, modifications of the phenyldihydropyrazolone scaffold are described. Variations were introduced by installing different substituents on the phenyl core, modifying the geminal dimethyl and installing various bio-isosteres of the dihydropyrazolone group. The anti T. cruzi activity of NPD-0227 could not be surpassed as the most potent compounds show pIC50 values of around 6.3. However, valuable additional SAR data for this interesting scaffold was obtained, and the data suggest that a scaffold hop is feasible as the pyrazolone moiety can be replaced by a oxazole or oxadiazole with minimal loss of activity.

COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF ABL1, ABL2 AND BCR-ABL1

The present invention relates to compounds of formula I: in which Y, Y1, Y 4, Y5, Y 6, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.

INSECTICIDAL ARYLPYRROLINES

The invention relates to novel arylpyrroline compounds of formula (I) which have excellent insecticidal activity and which can thus be used as insecticides.