6723-06-4

Basic information

• Product Name: 5-methyl-2,3-diphenyl-1-benzofuran
• CAS NO: 6723-06-4
• Molecular Formula: C₂₁H₁₆O
• Molecular Weight: 284.3511
• Mol File: 6723-06-4.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 415.5°C at 760 mmHg
• Flash Point: 212.1°C
• Density: 1.123g/cm³
• Vapor Pressure: 9.87E-07mmHg at 25°C
• Refractive Index: 1.632
• CAS DataBase Reference: 5-methyl-2,3-diphenyl-1-benzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2,3-diphenyl-1-benzofuran(6723-06-4)
• EPA Substance Registry System: 5-methyl-2,3-diphenyl-1-benzofuran(6723-06-4)

Safety Data

• Hazardous Substances Data: 6723-06-4(Hazardous Substances Data)

Upstream product

• 220464-86-8 N-(4-methylphenoxy)phthalimide 
• 65440-81-5 O-(4-methylphenyl)hydroxylamine 
• 501-65-5 diphenyl acetylene 
• 5720-05-8 4-methylphenylboronic acid 
• 1191950-68-1 1-methoxy-4-methyl-2-(2-phenylethynyl)benzene 
• 98-80-6 phenylboronic acid 
• 108-86-1 bromobenzene 
• 92-48-8 6-methylcoumarin 
• 106-44-5 p-cresol 
• 103-82-2 phenylacetic acid 
• 1470-57-1 2-hydroxy-5-methylbenzophenone 

Downstream Products

• 100698-26-8 6-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-3-(O-benzenesulphonyl)-4,5-dihydropyridazine 
• 100698-31-5 1-benzenesulphonyl-6-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-2,3,4,5-tetrahydropyridazine-3-one 
• 100698-30-4 4-[(Z)-2-Hydroxy-phenylimino]-4-(5-methyl-2,3-diphenyl-benzofuran-6-yl)-butyric acid ethyl ester 
• 100698-25-7 6-(5-Methyl-2,3-diphenyl-benzofuran-6-yl)-2-morpholin-4-ylmethyl-4,5-dihydro-2H-pyridazin-3-one 
• 100698-24-6 6-(5-Methyl-2,3-diphenyl-benzofuran-6-yl)-2-piperidin-1-ylmethyl-4,5-dihydro-2H-pyridazin-3-one 
• 100757-44-6 4-(5-Methyl-2,3-diphenyl-benzofuran-6-yl)-4-thiocarbamoylimino-butyric acid ethyl ester 
• 100698-28-0 6-(5-Methyl-2,3-diphenyl-benzofuran-6-yl)-3-phenyl-2,3,4,5-tetrahydro-pyridazin-3-ol 
• 100698-22-4 2-phenyl-6-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-2,3,4,5-tetrahydropyridazine-3-one 
• 100698-23-5 2-acetyl-6-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-2,3,4,5-tetrahydropyridazine-3-one 
• 100698-20-2 β-(diphenyl-5-methyl-6-benzofuranoyl)propionic ethyl ester 
• 100698-27-9 6-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-3-methoxy-4,5-dihydropyridazine 
• 100698-29-1 3-Ethyl-6-(5-methyl-2,3-diphenyl-benzofuran-6-yl)-2,3,4,5-tetrahydro-pyridazin-3-ol 
• 100698-21-3 6-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-2,3,4,5-tetrahydropyridazine-3-one 
• 100698-32-6 3-(2',3'-diphenyl-5'-methyl-6'-benzofuranyl)-4,5-dihydro-1,2-oxazin-6H-6-one 

Relevant articles and documents

Discovery of 4,6-bis(benzyloxy)-3-phenylbenzofuran as a novel Pin1 inhibitor to suppress hepatocellular carcinoma via upregulating microRNA biogenesis

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)participates in diverse cancer-associated signaling pathways, playing an oncogenic role in multiple human cancers, including hepatocellular carcinoma (HCC). Our recent works clarify that Pin1 modulates miRNAs biogenesis by interacting with ERK-phosphorylated exportin-5 (XPO5)and changing XPO5 conformation, giving a potential target for HCC treatment. Herein, we discover 4,6-bis(benzyloxy)-3-phenylbenzofuran (TAB29)as a novel Pin1 inhibitor that targets Pin1 PPIase domain. TAB29 potently inhibits Pin1 activity with the IC50 value of 874 nM and displays an excellent selectivity toward Pin1 in vitro. Cell-based biological evaluation reveals that TAB29 significantly suppresses cell proliferation of HCC cells through restoring the nucleus-to-cytoplasm export of XPO5 and upregulating mature miRNAs expression. Collectively, this work provides a promising small molecule lead compound for Pin1 inhibition, highlighting the therapeutic potential of miRNA-based treatment for human cancers.

A one-pot domino C-H, C-C activation in coumarins: A fast track to 2,3-diaryl benzo[b]furans

An approach to synthesize 2,3-diaryl benzo[b]furans using coumarins and aryl bromides is developed. This state-of-the-art strategy capitalizes on a palladium-catalyzed one-pot decarbonylative diarylation of coumarins, paving the way to achieve biologicall

Rhodium(III)-catalyzed redox-neutral coupling of N-phenoxyacetamides and alkynes with tunable selectivity

Give it a tweak: A novel oxidizing directing group was developed for a rhodium(III)-catalyzed C-H functionalization of N-phenoxyacetamides with alkynes. A small change in the reaction conditions leads to either ortho-hydroxyphenyl-substituted enamides or cyclization to deliver benzofurans with high selectivity (see scheme; Cp=C5Me5). Copyright