67237-87-0

Basic information

• Product Name: 3-(4-methylphenyl)isoquinoline
• Synonyms: 3-(4-methylphenyl)isoquinoline
• CAS NO: 67237-87-0
• Molecular Weight: 219.286
• Mol File: 67237-87-0.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 3-(4-methylphenyl)isoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methylphenyl)isoquinoline(67237-87-0)
• EPA Substance Registry System: 3-(4-methylphenyl)isoquinoline(67237-87-0)

Safety Data

• Hazardous Substances Data: 67237-87-0(Hazardous Substances Data)

Upstream product

• 194292-30-3 1-chloro-3-p-tolyl-isoquinoline 
• 5159-41-1 2-iodobenzyl alcohol 
• 189008-33-1 2-[2-(4-methylphenyl)ethynyl]benzaldehyde 
• 245122-91-2 (2-( p-tolylethynyl)phenyl)methanol 
• 766-97-2 4-n-methylphenylacetylene 
• 1138734-88-9 1-(azidomethyl)-2-(p-tolylethynyl)benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 106-38-7 para-bromotoluene 
• 4186-14-5 1-(2-(trimethylsilyl)ethynyl)toluene 
• 18904-38-6 N-benzyl-2-pyridinecarboxamide 
• 2227-58-9 3-(4-methylphenyl)prop-2-ynoic acid 
• 75159-10-3 N-(4-methylbenzylidene)-p-toluenesulfonamide 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 85-44-9 phthalic anhydride 

Relevant articles and documents

Silver/Rhodium Relay Catalysis Enables C?H Functionalization of In Situ Generated Isoquinolines with Sulfoxonium Ylides: Construction of Hexahydrodibenzo[a,g]quinolizine Scaffolds

Employing silver/rhodium relay catalysis strategy, an intramolecular electrophilic cyclization and C?H activation followed by cascade hydrogenation and reductive amination has been developed. The acylmethylated isoquinoline derivatives could be afforded with broad substrate scope in 23–88% yields, which could be further transformed to the core skeleton of hexahydrodibenzo[a,g]quinolizine as drug-candidates. Moreover, this reaction was achieved in a gram-scale. A reasonable reaction mechanism has been proposed based on a series of control and KIE experiments. (Figure presented.).

Cobalt-Mediated Decarboxylative/Desilylative C?H Activation/Annulation Reaction: An Efficient Approach to Natural Alkaloids and New Structural Analogues

A Co(II)-mediated decarboxylative/desilylative C?H activation/annulation reaction for the efficient synthesis of 3-arylisoquinolines has been developed. Using alkynyl carboxylic acid and alkynyl silane as terminal alkyne precursors, providing straightforw

Method for synthesizing isoquinoline compound

The invention discloses a method for synthesizing an isoquinoline compound. The isoquinoline compound is shown in formula I, wherein R1 is hydrogen, a halogen atom, an alkyl, an alkoxy or an amino, and R2 is hydrogen, a halogen atom, an alkyl, an alkoxy or an amino. According to the invention, o-alkynyl aldehyde and p-hydroxybenzylamine are used as raw materials to synthesize a target product through series reactions of imidization, cyclization and oxidation elimination, the method for synthesizing the isoquinoline compound is simple and rapid, the yield of the target compound is high, and a necessary basis is provided for further researching the compound in formula I or related compounds.