6724-42-1

Basic information

• Product Name: 8-Formyl-7-methoxycoumarin
• Synonyms: 7-Methoxy-8-formylcoumarin;8-Formyl-7-methoxycoumarin;Paniculal;7-methoxy-2-oxo-2H-chromene-8-carbaldehyde
• CAS NO: 6724-42-1
• Molecular Formula: C11H8O4
• Molecular Weight: 204
• Mol File: 6724-42-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 208-209℃
• Boiling Point: 424℃
• Flash Point: 194℃
• Appearance: /
• Density: 1.336
• CAS DataBase Reference: 8-Formyl-7-methoxycoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Formyl-7-methoxycoumarin(6724-42-1)
• EPA Substance Registry System: 8-Formyl-7-methoxycoumarin(6724-42-1)

Safety Data

• Hazardous Substances Data: 6724-42-1(Hazardous Substances Data)

Upstream product

• 4394-85-8 4-morpholinecarboxaldehyde 
• 65763-01-1 7-methoxy-8-iodo-2H-chromen-2-one 
• 10387-49-2 7-acetyloxycoumarin 
• 2067-86-9 8-formyl-7-hydroxycoumarin 
• 74-88-4 methyl iodide 
• 93-35-6 7-hydroxy-2H-chromen-2-one 
• 65763-00-0 7-hydroxy-8-iodocoumarin 
• 6545-99-9 Phebalosin 
• 124988-29-0 murrangatin 

Downstream Products

• 6545-99-9 8-(3-isopropenyloxiran-2-yl)-7-methoxy-2H-chromen-2-one 

Relevant articles and documents

A route to the structure proposed for puetuberosanol and approaches to the natural products marshrin and phebalosin

Synthesis of the structure claimed for puetuberosanol 1 (using the Juliá-Colonna oxidation in a key step) showed that the natural product was a different material. The isomeric epoxy alcohols 16-18 can be discounted from the alternatives. An analogue 19 of marshrin 2 was prepared but the synthesis of the natural product was thwarted by failure of a Juliá-Colonna oxidation in the key step. The epoxy ketone 29 was prepared by Darzens condensation and was converted into (±)-phebalosin 3.

ACID REARRANGEMENTS OF THE MURRANGATINS

Acid-catalyzed rearrangements of threo- murrangatin gave coumarins with tetrahydrofuryl side-chains, differences in reactivity from the erythro- isomer being attributed to stereoelectronic control.