67363-82-0Relevant articles and documents
Catalyst-Free Singlet Oxygen-Promoted Decarboxylative Amidation of α-Keto Acids with Free Amines
Xu, Wen-Tao,Huang, Bei,Dai, Jian-Jun,Xu, Jun,Xu, Hua-Jian
, p. 3114 - 3117 (2016/07/14)
A novel catalyst-free decarboxylative amidation of α-keto acids with amines under mild conditions has been developed. Advantages of the new protocol include avoidance of metal catalysts and high levels of functional group tolerance. In addition, the reaction can be scaled up and shows high chemoselectivity. Preliminary mechanistic studies suggest that singlet oxygen, generated from oxygen under irradiation, is the key promoter for this catalyst-free transformation.
Visible-light-mediated decarboxylation/oxidative amidation of α-keto acids with amines under mild reaction conditions using O2
Liu, Jie,Liu, Qiang,Yi, Hong,Qin, Chu,Bai, Ruopeng,Qi, Xiaotian,Lan, Yu,Lei, Aiwen
, p. 502 - 506 (2014/01/23)
Photochemistry has ushered in a new era in the development of chemistry, and photoredox catalysis has become a hot topic, especially over the last five years, with the combination of visible-light photoredox catalysis and radical reactions. A novel, simple, and efficient radical oxidative decarboxylative coupling with the assistant of the photocatalyst [Ru(phen)3]Cl 2 is described. Various functional groups are well-tolerated in this reaction and thus provides a new approach to developing advanced methods for aerobic oxidative decarboxylation. The preliminary mechanistic studies revealed that: 1)an SET process between [Ru(phen)3]2+* and aniline play an important role; 2)O2 activation might be the rate-determining step; and 3)the decarboxylation step is an irreversible and fast process. Bring to light: A new approach to oxidative decarboxylation under visible light using O2 as the oxidant has been developed. A variety of functional groups were well-tolerated in this reaction and insights into the mechanism were investigated with the assistance of EPR spectroscopy, cyclic voltammetry, and theoretical studies.
Investigating the spectrum of biological activity of substituted quinoline-2-carboxamides and their isosteres
Gonec, Tomas,Bobal, Pavel,Sujan, Josef,Pesko, Matus,Guo, Jiahui,Kralova, Katarina,Pavlacka, Lenka,Vesely, Libor,Kreckova, Eva,Kos, Jiri,Coffey, Aidan,Kollar, Peter,Imramovsky, Ales,Placek, Lukas,Jampilek, Josef
, p. 613 - 644 (2012/03/09)
In this study, a series of thirty-five substituted quinoline-2-carboxamides and thirty-three substituted naphthalene-2-carboxamides were prepared and characterized. They were tested for their activity related to the inhibition of photosynthetic electron t