6742-82-1

Basic information

• Product Name: 2-METHYL-5-TRIFLUOROMETHYL-1H-BENZIMIDAZOLE
• Synonyms: 2-METHYL-5-TRIFLUOROMETHYLBENZIMIDAZOLE;2-METHYL-5-TRIFLUOROMETHYL-1H-BENZIMIDAZOLE;1H-Benzimidazole, 2-methyl-5-(trifluoromethyl)-;1H-Benzimidazole,2-methyl-5-(trifluoromethyl)-(9CI);2-Methyl-5-trifluoromethyl-1H-benzoimidazole;2-Methyl-6-trifluoromethyl-1H-benzoimidazole;2-methyl-5-(trifluoromethyl)-1H-benzo[d]imidazole
• CAS NO: 6742-82-1
• Molecular Formula: C9H7F3N2
• Molecular Weight: 200.16
• Product Categories: BENZIMIDAZOLE
• Mol File: 6742-82-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-METHYL-5-TRIFLUOROMETHYL-1H-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-5-TRIFLUOROMETHYL-1H-BENZIMIDAZOLE(6742-82-1)
• EPA Substance Registry System: 2-METHYL-5-TRIFLUOROMETHYL-1H-BENZIMIDAZOLE(6742-82-1)

Safety Data

• Hazardous Substances Data: 6742-82-1(Hazardous Substances Data)

Usage

Uses

2-Methyl-5-(trifluoromethyl)-1H-benzimidazole

Upstream product

• 1445-45-0 Trimethyl orthoacetate 
• 400-98-6 4-trifluoromethyl-2-nitroaniline 
• 64-19-7 acetic acid 
• 108-24-7 acetic anhydride 
• 368-71-8 4-(trifluoromethyl)-1,2-phenylenediamine 

Relevant articles and documents

Indium-mediated one-pot benzimidazole synthesis from 2-nitroanilines or 1,2-dinitroarenes with orthoesters

One-pot reduction-triggered heterocyclizations from 2-nitroanilines or 1,2-dinitroarenes to benzimidazoles were investigated in this study. In the presence of indium/AcOH in ethyl acetate at reflux, reaction of 2-nitroanilines or 1,2-dinitroarenes with R-C(OMe)3 (R=Me, Ph) produced excellent yields of the corresponding benzimidazoles within 30 min to 6 h depending on the substituents of the starting materials. Indium-mediated heterocyclization of 2-nitroanilines to benzimidazole was faster and had better yields than 1,2-dinitroarenes to benzimidazole under similar reaction conditions.

Rapid one-pot preparation of 2-substituted benzimidazoles from 2-nitroanilines using microwave conditions

A high yielding one-pot procedure for the generation of 2-substituted benzimidazoles directly from 2-nitroanilines by in situ reduction and cyclization using a microwave procedure is described.