674283-98-8Relevant articles and documents
Discovery of novel 2-(4-aryl-2-methylpiperazin-1-yl)-pyrimidin-4-ones as glycogen synthase kinase-3β inhibitors
Kohara, Toshiyuki,Nakayama, Kazuki,Watanabe, Kazutoshi,Kusaka, Shin-ichi,Sakai, Daiki,Tanaka, Hiroshi,Fukunaga, Kenji,Sunada, Shinji,Nabeno, Mika,Saito, Ken-Ichi,Eguchi, Jun-ichi,Mori, Akiko,Tanaka, Shinji,Bessho, Tomoko,Takiguchi-Hayashi, Keiko,Horikawa, Takashi
, p. 3733 - 3738 (2017)
We herein describe the results of further evolution of glycogen synthase kinase (GSK)-3β inhibitors from our promising compounds containing a 3-methylmorpholine moiety. Transformation of the morpholine moiety into a piperazine moiety resulted in potent GS