67449-75-6Relevant articles and documents
Control of degradation reactions during radical functionalization of polypropylene in the melt
Coiai, Serena,Passaglia, Elisa,Aglietto, Mauro,Ciardelli, Francesco
, p. 8414 - 8423 (2004)
Isotactic polypropylene (iPP) gives very extensive degradation when treated with peroxides above its melting temperature in mechanical mixers or extruders. This undesired reaction is very modestly affected by maleate molecules which on the contrary actively compete with side reactions of macroradicals in the case of ethylene polymers. In this work iPP was treated in a Brabender mixer at 180°C with peroxide and different selected molecules capable of promptly reacting with the macroradical formed on iPP chain and converting it into a more stable free radical. Furan derivatives, successfully used for iPP cross-linking without any remarkable increase of MFR, were used as free radical removers and maleic anhydride as functionalizing monomer. The results indicate a detectable improvement with respect to the use of maleic monomers and peroxide only, allowing to us get a significant grafting of functional groups and only partial degradation. Moreover, furan derivatives bearing various reactive substituents were used as functionalizing molecules. The results are discussed in the frame of the general mechanism proposed for the free radical functionalization of polyolefin in the melt.
Silica bonded N-(propylcarbamoyl)sulfamic acid (SBPCSA) as a highly efficient and recyclable solid catalyst for the synthesis of Benzylidene Acrylate derivatives: Docking and reverse docking integrated approach of network pharmacology
Aslam, Afroz,Parveen, Mehtab,Alam, Mahboob,Silva, Manuela Ramos,Silva, P.S. Pereira
, (2020/08/17)
A green approach has been developed for the synthesis of a series of benzylidene acrylate 3(a-p) from differently substituted aromatic/heterocyclic aldehydes and ethyl cyanoacetate in excellent yields (90–98%), and employing silica bonded N-(Propylcarbamoyl)sulfamic acid as a recyclable catalyst under solvent-free condition. The molecular structure of compounds 3b, 3d and 3i were well supported by single-crystal X-ray crystallographic analysis. The present protocol bears wide substrate tolerance and is believed to be more practical, efficient, eco-friendly, and compatible as compared to existing methods. In-silico approaches were implemented to find the biochemical and physiological effects, toxicity, and biological profiles of the synthesized compounds to determine the expected biological nature and confirm a drug-like compound. A molecular docking study of the expected biologically active compound was performed to know the hypothetically binding mode with the receptor. Also, reverse docking is applied to recognize receptors from unknown protein targets for drug-like compounds to explain poly-pharmacology and binding postures with different receptors.
Oxidative Olefination of Benzylamine with an Active Methylene Compound Mediated by Hypervalent Iodine (III)
Rupanawar, Bapurao D.,Veetil, Sruthi M.,Suryavanshi, Gurunath
, p. 6232 - 6239 (2019/11/05)
Hypervalent iodine-mediated oxidative olefination of amines with an active methylene compound provides a rapid gateway towards the formation of electrophilic alkenes under mild reaction conditions in good to excellent yields. This is an efficient protocol for the preparation of substituted electrophilic alkenes.
