67450-63-9

Basic information

• Product Name: N-(3-Chloro-4-fluoro-phenyl)-N-((1R,2R)-2-dimethylamino-cyclopentyl)-propionamide
• CAS NO: 67450-63-9
• Molecular Weight: 312.815
• Mol File: 67450-63-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(3-Chloro-4-fluoro-phenyl)-N-((1R,2R)-2-dimethylamino-cyclopentyl)-propionamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-Chloro-4-fluoro-phenyl)-N-((1R,2R)-2-dimethylamino-cyclopentyl)-propionamide(67450-63-9)
• EPA Substance Registry System: N-(3-Chloro-4-fluoro-phenyl)-N-((1R,2R)-2-dimethylamino-cyclopentyl)-propionamide(67450-63-9)

Safety Data

• Hazardous Substances Data: 67450-63-9(Hazardous Substances Data)

Upstream product

• 87014-71-9 (±)-trans-2-(dimethylamino)cyclopentanol 
• 285-67-6 Cyclopentene oxide 
• 123-62-6 propionic acid anhydride 
• 367-21-5 3-chloro-4-fluorophenylamine 

Relevant articles and documents

A new nontricyclic antidepressant agent. Synthesis and activity of N-[trans-2-(dimethylamino)cyclopentyl]-N-(3,4-dichlorphenyl)propanamide and related compounds

A series of new nontricyclic antidepressant compounds was synthesized. A representative of this class is shown. Five structural parameters were investigated: ring size, cis/trans stereochemistry, amide substitution, aromatic substitution, and amine substi

N-(2-aminocyclopentyl)alkanoylanilides

N-(2-Aminocyclopentyl)N-alkanoylanilides and their 2-N-oxides of the formula STR1 e.g., trans-3,4-dichloro-N-[2-(dimethylamino)cyclopentyl]propionanilide, and their pharmacologically acceptable salts, have been found to possess potent Central Nervous System anti-depressant properties. Many of them are new. These compounds are promising anti-depressant drugs which are characterized by a better therapeutic ratio than imipramine, and long acting activity which may allow longer durations between administrations, e.g., once a day. Pharmaceutical compositions containing these compounds and a process for treating conditions of depression with these compositions are disclosed.