67476-67-9

Basic information

• Product Name: 2-AMINO-5-NITROPYRIDINE
• Synonyms: OTAVA-BB 7020151022
• CAS NO: 67476-67-9
• Molecular Formula: C5H5N3O2
• Molecular Weight: 139.11200
• Mol File: 67476-67-9.mol
• Article Data: 30

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMINO-5-NITROPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-NITROPYRIDINE(67476-67-9)
• EPA Substance Registry System: 2-AMINO-5-NITROPYRIDINE(67476-67-9)

Safety Data

• Hazardous Substances Data: 67476-67-9(Hazardous Substances Data)

Usage

Description

2-Amino-5-nitropyridine, with the molecular formula C5H5N3O2, is a yellow to orange crystalline solid. It is a chemical compound that serves as a versatile intermediate in the synthesis of various products, including pharmaceuticals, agrochemicals, dyes, and pigments. Due to its potential hazards, it requires careful handling and storage with appropriate safety measures.

Uses

Used in Pharmaceutical Industry:
2-Amino-5-nitropyridine is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique chemical structure allows for the creation of compounds with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Amino-5-nitropyridine is utilized as an intermediate in the production of agrochemicals, which are essential for enhancing crop protection and yield.
Used in Dye and Pigment Production:
2-Amino-5-nitropyridine is used as a building block in the creation of dyes and pigments, contributing to the coloration and properties of various materials in industries such as textiles, plastics, and inks.
Used in Organic Compound Synthesis:
As a versatile chemical intermediate, 2-Amino-5-nitropyridine is also used in the synthesis of other organic compounds, expanding its applications across different chemical and industrial processes.

Upstream product

• 504-29-0 2-aminopyridine 
• 26482-54-2 2-(nitroamino)pyridine 
• 7664-93-9 sulfuric acid 
• 456-24-6 2-Fluoro-5-nitropyridine 
• 2530-26-9 3-nitropyridine 
• 57-13-6 urea 
• 77287-34-4 formamide 
• 28148-12-1 2-(2,5-dimethyl-1H-pyrrol-1-yl)-5-nitropyridine 
• 35235-78-0 C₂₃H₁₈N₃O₂P 
• 4548-45-2 2-chloro-5-nitropyridine 
• 4487-59-6 2-bromo-5-nitropyridine 
• 15367-00-7 5-nitro-2-nitraminopyridine 
• 2127-09-5 2-mercapto-5-nitropyridine 
• 7664-41-7 ammonia 

Downstream Products

• 81438-60-0 ethyl 2-methyl-6-nitroimidazo[1,2-a]pyridine-3-carboxylate 
• 102592-88-1 (5-nitro-[2]pyridyl)-imidophosphoric acid triphenyl ester 
• 100124-60-5 N-(4-chloro-phenyl)-N'-(5-nitro-[2]pyridyl)-urea 
• 100137-20-0 1-(5-nitropyridin-2-yl)-3-phenylurea 
• 1766-60-5 N-(4-fluoro-phenyl)-N'-(5-nitro-[2]pyridyl)-urea 
• 104115-90-4 N-(3,5-dichloro-phenyl)-N'-(5-nitro-[2]pyridyl)-urea 
• 104116-34-9 N-(3,4-dichloro-phenyl)-N'-(5-nitro-[2]pyridyl)-urea 
• 28024-48-8 2-(5-nitro-pyridin-2-ylamino)-benzoic acid 
• 84858-94-6 [1-Methyl-piperidin-(2Z)-ylidene]-(5-nitro-pyridin-2-yl)-amine 
• 84858-93-5 [1-Butyl-pyrrolidin-(2Z)-ylidene]-(5-nitro-pyridin-2-yl)-amine 
• 134251-84-6 2-dimethylsulfylimino-5-nitropyridine 
• 84858-92-4 [1-Ethyl-pyrrolidin-(2Z)-ylidene]-(5-nitro-pyridin-2-yl)-amine 
• 84858-91-3 N-(1-methyl-2-pyrrolidinylidene)-2-amino-5-nitropyridine 
• 84858-95-7 [1-Methyl-azepan-(2Z)-ylidene]-(5-nitro-pyridin-2-yl)-amine 

Relevant articles and documents

One-pot synthesis method for synthesizing 2-hydroxy-5-nitropyridine

The invention discloses a one-pot synthesis method for synthesizing 2-hydroxy-5-nitropyridine. The method comprises the following specific reaction steps: adding 2-aminopyridine into concentrated sulfuric acid in batches, controlling the temperature at 10-20 DEG C, adding concentrated nitric acid, keeping the temperature at 40-50 DEG C, and stirring; after nitration is completed, adding reaction liquid into water for quenching, controlling the temperature to be 0-10 DEG C, dropwise adding a sodium nitrite aqueous solution, and carrying out diazo reaction; adding a proper amount of ammonia water to adjust the acid concentration; and filtering the solution after the acid concentration is adjusted, and drying a filter cake to obtain the product. The invention provides a novel preparation method of 2-hydroxy-5-nitropyridine. The method has the advantages that the post-treatment is simple, isomers are separated by utilizing the concentration of acid, and the isomers generated by nitration reaction do not need to be independently purified, the nitration reaction and the diazotization reaction are continuously operated, and thus the waste water generated in the amplified production is greatly reduced, and the production cost is saved; the preparation method is never reported in literatures, is a brand-new preparation method of the 2-hydroxy-5-nitropyridine, and provides a new synthesis thought for similar compounds of the 2-hydroxy-5-nitropyridine.

Preparation method of 2-amino substituted six-membered nitrogen-containing heterocycle complex

The invention discloses a preparation method of a 2-amino substituted six-membered nitrogen-containing heterocycle complex. The preparation method comprises the following steps: mix 2-fluorine substituted six-membered nitrogen-containing heterocycle complex and amidine hydrochloride salt compound, and then react under the action of a alkaline substance to obtain a 2-amino substituted six-memberednitrogen-containing heterocycle complex. Preferably, the 2-amino substituted six-membered nitrogen-containing heterocycle complex is a 2-amino pyridine compound, a 2-aminopyrimidine compound or a 2-aminopyrazine compound. Compared with the prior art, the method has the advantages of simple synthesis conditions, less reaction steps, mild reaction conditions, low cost of the catalyst used, less waste discharge and good functional group tolerance.

Synthesis of Amides by Nucleophilic Substitution of Hydrogen in 3-Nitropyridine

3-Nitropyridine reacted with nitrogen-centered carboxylic acid amide anions in anhydrous DMSO in the presence of K3Fe(CN)6 via oxidative nucleophilic substitution of hydrogen to give previously unknown N-(5-nitropyridin-2-yl) carboxa