675109-13-4

Basic information

• Product Name: 5H-1,2,4-Triazolo[3,4-a]isoindole, 3-(5-methyl-3-phenyl-4-isoxazolyl)-8-(2-methyl-4-pyridinyl)-
• CAS NO: 675109-13-4
• Molecular Formula: C25H19N5O
• Molecular Weight: 405.459
• Mol File: 675109-13-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5H-1,2,4-Triazolo[3,4-a]isoindole, 3-(5-methyl-3-phenyl-4-isoxazolyl)-8-(2-methyl-4-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 5H-1,2,4-Triazolo[3,4-a]isoindole, 3-(5-methyl-3-phenyl-4-isoxazolyl)-8-(2-methyl-4-pyridinyl)-(675109-13-4)
• EPA Substance Registry System: 5H-1,2,4-Triazolo[3,4-a]isoindole, 3-(5-methyl-3-phenyl-4-isoxazolyl)-8-(2-methyl-4-pyridinyl)-(675109-13-4)

Safety Data

• Hazardous Substances Data: 675109-13-4(Hazardous Substances Data)

Upstream product

• 675109-28-1 5-bromo-3-methoxy-1H-isoindolium trifluoromethanesulfonate 
• 675109-29-2 (6-bromo-3H-isoindol-1-yl)hydrazine 
• 87967-95-1 5-methyl-3-phenylisoxazole-4-carboxaldehyde 
• 22282-99-1 4-bromo-2-methylpyridine 
• 675108-96-0 8-bromo-3-(5-methyl-3-phenylisoxazol-4-yl)-5H-[1,2,4]triazolo[3,4-a]isoindole 
• 73183-34-3 bis(pinacol)diborane 

Relevant articles and documents

Cognition enhancing derivatives of isoxazole triazoloindane GABA-A alpha 5 receptor subunit ligands

The present invention relates to compounds of formula I: in which R1 is a linear group or a five membered heterocycle optionally fused to a phenyl ring, R2 is a 5-membered heterocycle, R3 is chosen from a range of substituents, m is 0-3 and n is 0 or 1; the compounds are generally inverse agonists at GABA-A receptors containing the alpha 5 subunit and so are useful in methods of enhancing cognition in subjects with diminished cognition in diseases such as Alzheimer's Disease.