675112-69-3

Basic information

• Product Name: Carbamic acid, (4-fluoro-3-cyclohexen-1-yl)-, 1,1-dimethylethyl ester (9CI)
• Synonyms: tert-Butyl (4-fluorocyclohex-3-en-1-yl)carbamate;tert-butyl 4-fluorocyclohex-3-enylcarbamate;Carbamic acid, (4-fluoro-3-cyclohexen-1-yl)-, 1,1-dimethylethyl ester (9CI);CARBAMIC ACID, (4-FLUORO-3-CYCLOHEXEN-1-YL)-, 1,1-DIMETHYLETHYL ESTER
• CAS NO: 675112-69-3
• Molecular Formula: C₁₁H₁₈FNO₂
• Molecular Weight: 215.2645232
• Product Categories: N-BOC
• Mol File: 675112-69-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 295.9±40.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 11.84±0.40(Predicted)
• CAS DataBase Reference: Carbamic acid, (4-fluoro-3-cyclohexen-1-yl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (4-fluoro-3-cyclohexen-1-yl)-, 1,1-dimethylethyl ester (9CI)(675112-69-3)
• EPA Substance Registry System: Carbamic acid, (4-fluoro-3-cyclohexen-1-yl)-, 1,1-dimethylethyl ester (9CI)(675112-69-3)

Safety Data

• Hazardous Substances Data: 675112-69-3(Hazardous Substances Data)

Upstream product

• 179321-49-4 N-(tert-butoxycarbonyl)-4-aminocyclohexanone 
• 24424-99-5 di-tert-butyl dicarbonate 
• 6850-65-3 p-hydroxycyclohexylamine 
• 224309-64-2 tert-butyl N-(4-hydroxycyclohexyl)carbamate 

Downstream Products

• 675112-67-1 tert-butyl (4,4-difluorocyclohexyl)carbamate 
• 675112-70-6 4,4-difluorocyclohexylamine hydrochloride 
• 675112-72-8 4-fluoro-3-cyclohexen-1-amine 

Relevant articles and documents

Eliminative Deoxofluorination Using XtalFluor-E: A One-Step Synthesis of Monofluoroalkenes from Cyclohexanone Derivatives

The eliminative deoxofluorination of cyclohexanone derivatives using XtalFluor-E is described. The corresponding monofluoroalkenes are obtained in up to 79% yield. Notably, this one-step procedure occurs at room temperature using readily accessible and cost-effective reagents.

THERAPEUTICALLY ACTIVE COMPOUNDS AND THEIR METHODS OF USE

Provided are methods of treating a cancer characterized by the presence of a mutant allele of IDH1/2 comprising administering to a subject in need thereof a compound described here.

Aminodifluorosulfinium salts: Selective fluorination reagents with enhanced thermal stability and ease of handling

Diethylaminodifluorosulfinium tetrafluoroborate (XtalFluor-E) and morpholinodifluorosulfinium tetrafluoroborate (XtalFluor-M) are crystalline fluorinating agents that are more easily handled and significantly more stable than Deoxo-Fluor, DAST, and their analogues. These reagents can be prepared in a safer and more cost-efficient manner by avoiding the laborious and hazardous distillation of dialkylaminosulfur trifluorides. Unlike DAST, Deoxo-Fluor, and Fluolead, XtalFluor reagents do not generate highly corrosive free-HF and therefore can be used in standard borosilicate vessels. When used in conjunction with promoters such as Et3N3HF, Et3N2HF, or DBU, XtalFluor reagents effectively convert alcohols to alkyl fluorides and carbonyls to gem-difluorides. These reagents are typically more selective than DAST and Deoxo-Fluor and exhibit superior performance by providing significantly less elimination side products.