67527-71-3

Basic information

• Product Name: Mildiomycin
• Synonyms: Mildiomycin;4-Amino-1-[4-[[(S)-2-amino-3-hydroxy-1-oxopropyl]amino]-9-guanidino-6-carboxy-2,3,4,7,9-pentadeoxy-α-L-talo-non-2-enopyranosyl]-5-(hydroxymethyl)pyrimidin-2(1H)-one;4-Amino-1-[4-[[(S)-2-amino-3-hydroxy-1-oxopropyl]amino]-9-guanidino-6-carboxy-2,3,4,7,9-pentadeoxy-α-L-talo-nona-2-enopyranosyl]-5-(hydroxymethyl)pyrimidin-2(1H)-one;Antibiotic B-98891;TF-138
• CAS NO: 67527-71-3
• Molecular Formula: C₁₉H₃₀N₈O₉
• Molecular Weight: 514.493
• Mol File: 67527-71-3.mol
• Article Data: 0

Chemical Properties

• Melting Point: >300° (monohydrate)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.81g/cm³
• Refractive Index: 1.743
• PKA: 2.8, 4.3, 7.2, >12(at 25℃)
• CAS DataBase Reference: Mildiomycin(CAS DataBase Reference)
• NIST Chemistry Reference: Mildiomycin(67527-71-3)
• EPA Substance Registry System: Mildiomycin(67527-71-3)

Safety Data

• Hazardous Substances Data: 67527-71-3(Hazardous Substances Data)

Usage

Description

Mildiomycin is a nucleoside antibiotic that is isolated from the culture filtrate of Streptoverticillium rimofaciens B-98891. It has a molecular formula of C19H30N8O9 and a molecular weight of 514.5. Mildiomycin is a basic and hygroscopic compound that is soluble in water, methanol, and ethanol, but insoluble in ethyl acetate and ethyl ether. It is also susceptible to photodegradation by sunlight.

Uses

Used in Agriculture:
Mildiomycin is used as a biopesticide for the control of powdery mildews on various plants. It exhibits excellent curative activity against the disease in vivo and is specifically active against powdery mildew pathogens.
Used in Plant Protection:
Mildiomycin is used in practice for the control of powdery mildews on rose, spindle tree, and Indian lilac. Its effectiveness in controlling these diseases helps to protect the health and yield of these plants.

Toxicity evaluation

Mildiomycin remarkably inhibits protein synthesis in E. coli. The synthesis of polypeptides in mammalian cellfree system from rabbit reticulocytes is less sensitive to mildiomycin than that from E. coli (18). The toxicity of mildiomycin is low; LD50 for acute toxicity in rats and mice is 500–1000 mg/kg by intravenous and subcutaneous injections, and 2.5–5.0 g/kg by oral administration. At a concentration of 1000 ppm, there is no irritation to the cornea and skin of rabbits for 10 days.

InChI:InChI=1/C19H30N8O9/c20-10(7-29)15(31)25-11-1-2-12(27-5-8(6-28)14(21)26-18(27)34)36-13(11)19(35,16(32)33)3-9(30)4-24-17(22)23/h1-2,5,9-13,28-30,35H,3-4,6-7,20H2,(H,25,31)(H,32,33)(H2,21,26,34)(H4,22,23,24)

Downstream Products

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