6755-57-3

Basic information

• Product Name: 1-methyl-5-phenyl-1,2,3,4-tetrahydropyridine
• Synonyms: 1-methyl-5-phenyl-1,2,3,4-tetrahydropyridine
• CAS NO: 6755-57-3
• Molecular Weight: 173.258
• Mol File: 6755-57-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-methyl-5-phenyl-1,2,3,4-tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-methyl-5-phenyl-1,2,3,4-tetrahydropyridine(6755-57-3)
• EPA Substance Registry System: 1-methyl-5-phenyl-1,2,3,4-tetrahydropyridine(6755-57-3)

Safety Data

• Hazardous Substances Data: 6755-57-3(Hazardous Substances Data)

Upstream product

• 119346-11-1 α-(N-methylaminopropyl)styrene 
• 123934-18-9 chlorure de 1-methyl-3-phenylpyridinium 
• 60684-91-5 iodure de 1-methyl-3-phenylpyridinium 
• 1008-88-4 3-phenylpyridine 

Downstream Products

• 180407-33-4 (RS) 1-methyl-2-phenylpyrrolidine-2-carbaldehyde 

Relevant articles and documents

Rhodium-catalyzed intramolecular, anti-Markovnikov hydroamination. Synthesis of 3-arylpiperidines

The intramolecular anti-Markovnikov hydroamination of 1-(3-aminopropyl)vinylarenes in the presence of a readily available rhodium catalyst to form 3-arylpiperidines is reported. In contrast to intermolecular hydroamination of vinylarenes, which occurred in high yields in the presence of rhodium catalysts containing DPEphos, the intramolecular reaction occurred in high yield in the presence of [Rh(COD)(DPPB)]BF4 as catalyst. Reactants with substituents β to the nitrogen occurred in high yield, and these reactions formed 3,5-disubstituted piperidines with high diastereomeric excess. The regiochemistry of these cyclizations contrasts with the regiochemistry of intramolecular hydroaminations catalyzed by lanthanide complexes, group III metal complexes, and platinum complexes, all of which have been reported to form cyclization products from Markovnikov addition. Copyright