676-84-6 Usage
Description
Trimethylsulfonium is a sulfonium compound characterized by three methyl groups as substituents on the sulfur atom. It is naturally found in the midgut gland of the sea hare, Aplysia brasiliana, and is known for its potential to inhibit cholinergic responses.
Uses
Used in Pharmaceutical Industry:
Trimethylsulfonium is used as a reagent for the preparation of spirastrellolide A Me ester, which is a compound with antitumor activity. The synthesis process involves various techniques such as Suzuki coupling, Yamaguchi lactonization, Julia-Kocienski olefination, bond cleavage, and ozonolysis. Additionally, trimethylsulfonium plays a role in studying the structure-activity relationship (SAR) with truncated variants of the compound.
Used in Research and Development:
Trimethylsulfonium is utilized in the research and development of new pharmaceutical compounds, particularly in the field of cancer treatment. Its ability to inhibit cholinergic responses makes it a valuable compound for exploring potential applications in the development of novel therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 676-84-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,7 and 6 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 676-84:
(5*6)+(4*7)+(3*6)+(2*8)+(1*4)=96
96 % 10 = 6
So 676-84-6 is a valid CAS Registry Number.
InChI:InChI=1/C3H9S.NO3/c1-4(2)3;2-1(3)4/h1-3H3;/q+1;-1
676-84-6Relevant articles and documents
Sunlight-driven trifluoromethylation of olefinic substrates by photoredox catalysis: A green organic process
Akita, Munetaka,Koike, Takashi
, p. 742 - 751 (2015/07/15)
The principles and utility of photoredox catalysis in organic synthesis are described. After a brief description of the features of the two types of catalytic photoredox processes following the reductive quenching cycle (RQC) and the oxidative quenching cycle (OQC), the discussion is focused on organic transformations based on OQC, in particular the trifluoromethylation of olefinic substrates with electrophilic trifluoromethylating reagents furnishing solvolytic addition products and substitution products. It is concluded that catalytic photoredox systems are green from the point of view of harmfulness, safety, and energy source (visible light, including sunlight). Future prospects of photoredox catalysis will be also discussed.
