67608-58-6

Basic information

• Product Name: 5-AMINO-2-HYDROXYBENZONITRILE
• Synonyms: 4-amino-2-hydroxybenzonitrile
• CAS NO: 67608-58-6
• Molecular Formula: C₇H₆N₂O
• Molecular Weight: 134.14
• Mol File: 67608-58-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 158-160 °C
• Boiling Point: 376.2 °C at 760 mmHg
• Flash Point: 181.3 °C
• Appearance: /
• Density: 1.33 g/cm³
• Vapor Pressure: 3.41E-06mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.22±0.10(Predicted)
• CAS DataBase Reference: 5-AMINO-2-HYDROXYBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-2-HYDROXYBENZONITRILE(67608-58-6)
• EPA Substance Registry System: 5-AMINO-2-HYDROXYBENZONITRILE(67608-58-6)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38-36
• Safety Statements: 26-36/37/39
• RIDADR: 3439
• Hazardous Substances Data: 67608-58-6(Hazardous Substances Data)

Usage

General Description

5-Amino-2-Hydroxybenzonitrile, also known as 2-Amino-5-cyano-phenol, is a chemical compound with the molecular formula C7H6N2O. It is a crystalline solid with a white to light yellow color. This chemical is used as an intermediate in the synthesis of various pharmaceutical compounds and organic chemicals. It has been investigated for its potential applications in the production of dyes and pigments. Additionally, 5-Amino-2-Hydroxybenzonitrile has been studied for its biological activities, including its potential as an antioxidant and its ability to inhibit the growth of certain bacteria and fungi. However, further research is needed to fully understand its properties and potential uses.

InChI:InChI=1/C7H6N2O/c8-4-5-3-6(9)1-2-7(5)10/h1-3,10H,9H2

Upstream product

• 7251-09-4 4-amino-2-methoxybenzonitrile 
• 3236-33-7 2,4-dinitro-benzaldehyde-oxime 
• 121-14-2 2,4-dinitrotoluene 
• 101084-96-2 2-methoxy-4-nitrobenzonitrile 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 5453-86-1 methyl 6-nitro-1,2-benzisoxazole-3-carboxylate 
• 28691-46-5 6-amino-benzo[d]isoxazole-3-carboxylic acid 
• 39835-14-8 2-hydroxy-4-nitro-benzonitrile 
• 98-95-3 nitrobenzene 

Downstream Products

• 7251-09-4 4-amino-2-methoxybenzonitrile 
• 417716-92-8 lenvatinib 
• 417721-36-9 4‐chloro‐7‐methoxyquinoline‐6‐carboxamide 
• 398487-31-5 4-chloro-7-methoxyquinoline-6-carbonitrile 
• 1532507-13-3 C₁₅H₁₂N₂O₃ 
• 1532507-28-0 C₂₂H₂₁N₃O₅S₂ 
• 1532507-22-4 C₂₀H₁₉N₃O₅S 
• 933045-53-5 C₁₅H₁₀N₄O 

Relevant articles and documents

Discovery of meta-amido bromophenols as new antitubercular agents

A series of meta-amido bromophenol derivatives were designed and synthesized. The compounds were found to potently inhibit the growth of Mycobacterium tuberculosis H37Ra. They also exhibited moderate inhibitory activity against Mycobacterium tuberculosis H37Rv and multidrug-resistant strains. The compounds did not show inhibitory activity against normal Gram-positive and Gram-negative bacteria. Moderate cytotoxicities and good metabolic stability were observed for the selected compounds. The results demonstrated meta-amido bromophenols as a new class of antitubercular agents with good potentials.

COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRUSES AND CANCER

The present invention relates to compounds according to the formula I: Where Ra is H or an optionally OH-substituted C1-C3 alkyl; R1 is OR1, an optionally substituted C4-12 carbocyclic group which may be saturated or unsaturated (including aromatic) or an optionally substituted heterocyclic group; R1 is an optionally substituted C1-C14 hydrocarbyl group or an optionally substituted heterocyclic group;; R2 , R3 and R4 are each independently H, an optionally substituted C1-C4 alkyl group (preferably CH3, CH2CH3 or CF3), halogen (preferably F, Cl, Br), OR, CN, NO2, a C1-C6 thioether, a C1-C6 thioester group, an optionally substituted CO2R group, an optionally substituted COR group or an optionally substituted OCOR group (preferably R4 is H); R is H or an optionally substituted C1-C6 alkyl group; RHET is an optionally substituted heterocyclic group; and pharmaceutically acceptable salts, solvates or polymorphs thereof.

N-(4-carb-amimidophenyl)glycineamide derivatives

N-(4-carbamimidophenylamino) phenylglycineamide derivative compounds having the formula: in which E, g1, g2, Q, R and X1 to X4 are each as defined in the description, and hydrates or solvates and physiologically acceptable salts thereof can be used as inhibitors of the formation of the coagulation factors Xa, IXa and thrombin induced by the factor VIIa and by the tissue factor. These compounds can be used as medicaments for the treatment and/or prevention of thromboses, apoplexy, cardiac infarction, inflammation and arteriosclerosis or as antitumor agents.