67625-38-1

Basic information

• Product Name: 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;6-CHLOROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER;ETHYL 6-CHLOROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLATE;BUTTPARK 154\50-01;6-CHLOROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER, 95+%
• CAS NO: 67625-38-1
• Molecular Formula: C₁₀H₉ClN₂O₂
• Molecular Weight: 224.65
• EINECS: 604-604-1
• Product Categories: blocks;Carboxes;Pyridines;Esters;Fused Ring Systems
• Mol File: 67625-38-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 112-114°
• Appearance: /
• Density: 1.36g/cm3
• Refractive Index: 1.613
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 1.67±0.50(Predicted)
• CAS DataBase Reference: 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(67625-38-1)
• EPA Substance Registry System: 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER(67625-38-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 67625-38-1(Hazardous Substances Data)

Usage

General Description

6-Bromo-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester is a chemical compound with the molecular formula C9H8BrN3O2. It is a derivative of the imidazo[1,2-a]pyridine family, commonly used in the synthesis of pharmaceuticals and agrochemicals. 6-BROMO-IMIDAZO[1,2-A]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER is a potent inhibitor of the enzyme Cdc7 kinase, which plays a critical role in the regulation of cell cycle progression. As a result, 6-Bromo-imidazo[1,2-a]pyridine-2-carboxylic acid ethyl ester has potential applications in cancer research and drug development. Additionally, its ethyl ester form makes it more soluble in organic solvents, enhancing its utility in chemical reactions and synthesis processes. However, it is important to handle this compound with care, as it may present health hazards if not properly managed.

InChI:InChI=1/C10H9ClN2O2/c1-2-15-10(14)8-6-13-5-7(11)3-4-9(13)12-8/h3-6H,2H2,1H3

Upstream product

• 1072-98-6 5-chloro-2-pyridylamine 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 182181-19-7 6-chloroimidazo[1,2-a]pyridine-2-carboxylic acid 
• 1039416-36-8 6-chloroimidazo[1,2-a]pyridine-2-yl-methanol 
• 1312585-65-1 ethyl 6-chloro-3-(3-fluorophenyl)imidazo[1,2-a]pyridine-2-carboxylate 

Relevant articles and documents

Improving the Potency of N-Aryl-2,5-dimethylpyrroles against Multidrug-Resistant and Intracellular Mycobacteria

A series of N-phenyl-2,5-dimethylpyrrole derivatives, designed as hybrids of the antitubercular agents BM212 and SQ109, have been synthesized and evaluated against susceptible and drug-resistant mycobacteria strains. Compound 5d, bearing a cyclohexylmethylene side chain, showed high potency against M. tuberculosis including MDR-TB strains at submicromolar concentrations. The new compound shows bacteriostatic activity and low toxicity and proved to be effective against intracellular mycobacteria too, showing an activity profile similar to isoniazid.

SUBSTITUTED HETEROARYL FUSED DERIVATIVES AS PI3K INHIBITORS

The present invention provides fused derivatives of Formula (I) that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PBKs including, for example, inflammatory disorders, immune- based disorders, cancer, and other diseases.