67646-68-8

Basic information

• Product Name: 3-methyl-5-phenylpent-1-yne-3-ol
• CAS NO: 67646-68-8
• Molecular Weight: 174.243
• Mol File: 67646-68-8.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 3-methyl-5-phenylpent-1-yne-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-5-phenylpent-1-yne-3-ol(67646-68-8)
• EPA Substance Registry System: 3-methyl-5-phenylpent-1-yne-3-ol(67646-68-8)

Safety Data

• Hazardous Substances Data: 67646-68-8(Hazardous Substances Data)

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 
• 75-20-7 calcium carbide 
• 1066-54-2 trimethylsilylacetylene 
• 1449379-52-5 C₁₅H₂₂OSi 
• 1777-03-3 2-triethylsilylacetylene 
• 74866-72-1 3-Methyl-5-phenyl-2-phenylselanyl-pent-1-en-3-ol 
• 65032-27-1 ethynylmagnesium chloride 
• 74-86-2 acetylene 
• 925-90-6 ethylmagnesium bromide 
• 4301-14-8 acetylenemagnesium bromide 

Downstream Products

• 159028-45-2 3-methyl-5-phenylpent-1-yn-3-yl acetate 
• 1449379-54-7 C₁₈H₁₇N₃O 
• 1449379-55-8 1-(2-azidophenyl)-3-methyl-5-phenylpent-1-yn-3-yl acetate 
• 1449379-98-9 C₂₀H₁₉NO₂ 
• 1449379-53-6 C₁₈H₁₉NO 
• 83542-41-0 (E)-3-methyl-5-phenyl-4-pentene-2-one 
• 83520-80-3 (E)-3-methyl-5-phenylpent-3-en-2-one 
• 1624363-22-9 C₁₂H₁₅N₃O 
• 110211-32-0 (3-methylnona-3,4-dienyl)benzene 
• 1448195-68-3 C₁₆H₂₂ 

Relevant articles and documents

Ligand-Controlled Palladium-Catalyzed Carbonylation of Alkynols: Highly Selective Synthesis of α-Methylene-β-Lactones

The first general and regioselective Pd-catalyzed cyclocarbonylation to give α-methylene-β-lactones is reported. Key to the success for this process is the use of a specific sterically demanding phosphine ligand based on N-arylated imidazole (L11) in the presence of Pd(MeCN)2Cl2 as pre-catalyst. A variety of easily available alkynols provide under additive-free conditions the corresponding α-methylene-β-lactones in moderate to good yields with excellent regio- and diastereoselectivity. The applicability of this novel methodology is showcased by the direct carbonylation of biologically active molecules including natural products.

Catalytic Nucleophilic Fluorination of Secondary and Tertiary Propargylic Electrophiles with a Copper-N-Heterocyclic Carbene Complex

A catalytic method for the nucleophilic fluorination of propargylic electrophiles is described. Our protocol involves the use of a Cu(NHC) complex as the catalyst and is suitable for the preparation of secondary and tertiary propargylic fluorides without

Mild conversion of propargylic alcohols to α,β-unsaturated enones in ionic liquids (ILs); A new 'metal free' life for the Rupe rearrangement

A mild and selective transition metal free protocol for the conversion of propargylic alcohols to cyclic and acyclic α,β-unsaturated enones via the Rupe rearrangement is reported. The method utilizes the Br?nsted acidic ionic liquid [BMIM-SO3H][OTf] as catalyst and [BMIM][PF 6] as solvent and offers the potential for recycling and reuse of the IL solvent. The feasibility to synthesize bicyclic fused cyclopentenone derivatives via a Rupe → Aldol → Nazarov sequence utilizing this protocol has also been demonstrated.