676491-02-4

Basic information

• Product Name: METHYL-(2H-PYRAZOL-3-YLMETHYL)-AMINE
• Synonyms: AKOS B029937;AKOS PAO-0494;METHYL-(2H-PYRAZOL-3-YLMETHYL)-AMINE;N-methyl-1-(1H-pyrazol-3-yl)methanamine;Methyl-(2H-pyrazole-3-ylmethyl)-amine;Methyl-(1H-pyrazol-3-ylmethyl)-amine;N-methyl-1-(1H-pyrazol-5-yl)methanamine(SALTDATA: 1.15C2H2O4);1H-Pyrazole-3-MethanaMine, N-Methyl-
• CAS NO: 676491-02-4
• Molecular Formula: C₅H₉N₃
• Molecular Weight: 111.15
• Mol File: 676491-02-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 243.642 °C at 760 mmHg
• Flash Point: 101.151 °C
• Appearance: /
• Density: 1.083 g/cm³
• Vapor Pressure: 0.032mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: 2-8°C
• CAS DataBase Reference: METHYL-(2H-PYRAZOL-3-YLMETHYL)-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL-(2H-PYRAZOL-3-YLMETHYL)-AMINE(676491-02-4)
• EPA Substance Registry System: METHYL-(2H-PYRAZOL-3-YLMETHYL)-AMINE(676491-02-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 676491-02-4(Hazardous Substances Data)

Usage

General Description

Methyl-(2H-pyrazol-3-ylmethyl)-amine is a chemical compound with the molecular formula C6H10N2. It is a derivative of pyrazole, a five-membered aromatic ring with two nitrogen atoms. Methyl-(2H-pyrazol-3-ylmethyl)-amine is commonly used as a building block in organic synthesis for the production of various pharmaceuticals and agrochemicals. Its structure and reactivity make it a valuable intermediate for the preparation of diverse molecules with potential biological activities. It is also used in the production of fine chemicals, dyes, and pigments. Additionally, it is utilized as a reagent in chemical research and laboratory experiments.

InChI:InChI=1/C5H9N3/c1-6-4-5-2-3-7-8-5/h2-3,6H,4H2,1H3,(H,7,8)

Upstream product

• 23784-89-6 3-(chloromethyl)-1H-pyrazole 
• 74-89-5 methylamine 

Downstream Products

• 701213-08-3 1-(4-benzoylpiperazin-1-yl)-2-(4-methoxy-7-(3-((methylamino)methyl)-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione 

Relevant articles and documents

SUBSTITUTED PYRIDINES AS INHIBITORS OF DNMT1

The invention is directed to substituted pyridine derivatives. Specifically, the invention is directed to compounds according to Formula (Iar): (Iar) wherein Yar, X1ar, X2ar, R1ar, R2ar, R3ar, R4ar and R5ar are as defined herein; or a pharmaceutically acceptable salt or prodrug thereof. The compounds of the invention are selective inhibitors of DNMT1 and can be useful in the treatment of cancer, pre-cancerous syndromes, beta hemoglobinopathy disorders, sickle cell disease, sickle cell anemia, and beta thalassemia, and diseases associated with DNMT1 inhibition. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT1 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides

This invention provides compounds having drug and bio-affecting properties, their pharmaceutical compositions and method of use. In particular, the invention is concerned with new piperidine 4-alkenyl derivatives that possess unique antiviral activity. More particularly, the present invention relates to compounds useful for the treatment of HIV and AIDS. The compounds of the invention for the general Formula I: wherein: Z is Q is selected from the group consisting of: —W— is