676517-52-5

Basic information

• Product Name: Piperidine, 1-(3-cyclopenten-1-ylcarbonyl)-4-(3,4-dichlorophenoxy)-
• CAS NO: 676517-52-5
• Molecular Formula: C17H19Cl2NO2
• Molecular Weight: 340.249
• Mol File: 676517-52-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Piperidine, 1-(3-cyclopenten-1-ylcarbonyl)-4-(3,4-dichlorophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 1-(3-cyclopenten-1-ylcarbonyl)-4-(3,4-dichlorophenoxy)-(676517-52-5)
• EPA Substance Registry System: Piperidine, 1-(3-cyclopenten-1-ylcarbonyl)-4-(3,4-dichlorophenoxy)-(676517-52-5)

Safety Data

• Hazardous Substances Data: 676517-52-5(Hazardous Substances Data)

Upstream product

• 245057-73-2 4-(3,4-dichloro-phenoxy)-piperidine 
• 3744-80-7 cyclopent-3-ene-1-carboxylic acid chloride 
• 7686-77-3 3-cyclopentene-1-carboxylic acid 
• 676517-51-4 4-(3,4-dichlorophenoxy)-1-[1-oxo-2-(2-propenyl)-4-pentenyl]piperidine 

Downstream Products

• 676517-53-6 4-(3,4-dichlorophenoxy)-1-[(3,4-dihydroxycyclopentyl)carbonyl]piperidine 
• 921204-75-3 methyl (2S)-2-[4-[[4-(3,4-dichlorophenoxy)-1-piperidyl]methyl]-1-piperidyl]-2-methyl-3-phenylpropanoate 
• 921204-71-9 methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate 
• 676518-10-8 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(S)-phenyl-1-piperidineacetic acid 
• 676517-70-7 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetic acid 
• 676517-69-4 methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(S)-phenyl-1-piperidineacetate 
• 676517-68-3 methyl 4-[[4-(3,4-dichlorophenoxy)-1-piperidinyl]methyl]-α-(R)-phenyl-1-piperidineacetate 
• 676517-50-3 4-[4-(3,4-dichloro-phenoxy)-piperidin-1-ylmethyl]-cyclopentane-1,2-diol 
• 770741-96-3 C₁₇H₂₁Cl₂NO₃ 

Relevant articles and documents

Scaffold-hopping with zwitterionic CCR3 antagonists: Identification and optimisation of a series with good potency and pharmacokinetics leading to the discovery of AZ12436092

The discovery and optimisation of a series of zwitterionic CCR3 antagonists is described. Optimisation of the structure led to AZ12436092, a compound with excellent selectivity over activity at hERG and outstanding pharmacokinetics in preclinical species.

NOVEL PIPERIDINE DERIVATIVES FOR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASE STATES

The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.