67671-05-0

Basic information

• Product Name: exo-bicyclo<2.2.1>hept-5-en-2-methanol
• Synonyms: exo-bicyclo<2.2.1>hept-5-en-2-methanol
• CAS NO: 67671-05-0
• Molecular Weight: 124.183
• Mol File: 67671-05-0.mol
• Article Data: 53

Chemical Properties

• CAS DataBase Reference: exo-bicyclo<2.2.1>hept-5-en-2-methanol(CAS DataBase Reference)
• NIST Chemistry Reference: exo-bicyclo<2.2.1>hept-5-en-2-methanol(67671-05-0)
• EPA Substance Registry System: exo-bicyclo<2.2.1>hept-5-en-2-methanol(67671-05-0)

Safety Data

• Hazardous Substances Data: 67671-05-0(Hazardous Substances Data)

Upstream product

• 120-74-1 (1S,2S,4S)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid 
• 120-74-1 endo-norbornenecarboxylic acid 
• 10138-32-6 ethyl bicyclo[2.2.1]hept-5-ene-2-carboxylate 
• 4835-96-5 (-)-menthyl acrylate 
• 542-92-7 cyclopenta-1,3-diene 
• 96303-89-8 2-exo-acryloyloxy-N,N-dicyclohexylbornane-10-sulfonamide 
• 94594-91-9 acrylcamphorsultam 
• 89156-14-9 Acrylic acid (1S,2R,4R)-1-benzenesulfonylmethyl-7,7-dimethyl-bicyclo[2.2.1]hept-2-yl ester 
• 96304-11-9 Acrylic acid (1S,2R,4R)-7,7-dimethyl-1-(naphthalene-1-sulfonylmethyl)-bicyclo[2.2.1]hept-2-yl ester 
• 96304-12-0 Acrylic acid (1S,2R,4R)-7,7-dimethyl-1-(naphthalene-2-sulfonylmethyl)-bicyclo[2.2.1]hept-2-yl ester 
• 96304-14-2 Acrylic acid (1S,2R,4R)-7,7-dimethyl-1-(2,4,6-trimethyl-benzenesulfonylmethyl)-bicyclo[2.2.1]hept-2-yl ester 
• 96304-13-1 Acrylic acid (1S,2R,4R)-7,7-dimethyl-1-(phenanthrene-9-sulfonylmethyl)-bicyclo[2.2.1]hept-2-yl ester 
• 72526-00-2 (-)-8-phenylmenthyl acrylate 
• 85718-79-2 (1S,2S,4S)-Bicyclo[2.2.1]hept-5-ene-2-carboxylic acid (1R,2S,3R,4S)-3-(2,2-dimethyl-propoxy)-4,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl ester 

Downstream Products

• 42070-73-5 Toluene-4-sulfonic acid (1S,2S,4S)-1-bicyclo[2.2.1]hept-5-en-2-ylmethyl ester 
• 42070-73-5 Toluene-4-sulfonic acid (1S,2R,4S)-1-bicyclo[2.2.1]hept-5-en-2-ylmethyl ester 
• 135560-47-3 (+/-)-exo-bicyclo[2.2.1]hept-5-en-2-ylmethyl benzoate 
• 211758-35-9 bicyclo[2.2.1]hept-5-ene-2-methyl benzoate 
• 135560-61-1 ((1R,2R,4R,5S,6S)-6-Chloro-5-phenylsulfanyl-bicyclo[2.2.1]hept-2-yl)-methanol 
• 135583-61-8 ((1S,2S,4S,5S,6S)-5-Chloro-6-phenylsulfanyl-bicyclo[2.2.1]hept-2-yl)-methanol 

Relevant articles and documents

Method for preparing single-configuration C-2-position-monosubstituted norbornene derivative

The invention discloses a method for preparing a single-configuration C-2-position-monosubstituted norbornene derivative. The method comprises the following steps of: firstly, preparing exo-isomer enriched exo-isomer mixed 5-norbornene-2-carboxylic ester by taking commercial exo-isomer/endoisomer mixed 5-norbornene-2-carboxylic acid and large-steric-hindrance monohydric alcohol as raw materials; separating 5-norbornene-2-carboxylate with a single configuration through common column chromatography separation or fractionation; and finally, preparing the C-2-position-monosubstituted norbornene derivative with the single configuration from the separated 5-norbornene-2-carboxylate with the single configuration. The raw materials used in the invention are easy to obtain, the preparation process is simple, and the C-2-position-monosubstituted norbornene derivative with high purity (greater than 98%) and single configuration can be obtained.

Amphiphilic Bottlebrush Block Copolymers: Analysis of Aqueous Self-Assembly by Small-Angle Neutron Scattering and Surface Tension Measurements

A systematic series of 16 amphiphilic bottlebrush block copolymers (BCPs) containing polystyrene and poly(N-acryloylmorpholine) (PACMO) side chains were prepared by a combination of atom-transfer radical polymerization (ATRP), photoiniferter polymerization, and ring-opening metathesis polymerization (ROMP). The grafting-through method used to prepare the polymers enabled a high degree of control over backbone and side-chain molar masses for each block. Surface tension measurements on the self-assembled amphiphilic bottlebrush BCPs in water revealed an ultralow critical micelle concentration (cmc), 1-2 orders of magnitude lower than linear BCP analogues on a molar basis, even for micelles with >90% PACMO content. Combined with coarse-grained molecular dynamics simulations, fitting of small-angle neutron scattering traces (SANS) allowed us to evaluate solution conformations for individual bottlebrush BCPs and micellar nanostructures for self-assembled macromolecules. Bottlebrush BCPs showed an increase in anisotropy with increasing PACMO content in toluene-d8, which is a good solvent for both blocks, reflecting an extended conformation for the PACMO block. SANS traces of bottlebrush BCPs assembled into micelles in D2O, a selective solvent for PACMO, were fitted to a core-shell-shell model, suggesting the presence of a partially hydrated inner shell. Results showed an average micelle diameter of 40 nm with combined shell diameters ranging from 16 to 18 nm. A general trend of increased stability of micelles (i.e., resistance to precipitation) was observed with increases in PACMO content. These results demonstrate the stability of bottlebrush polymer micelles, which self-assemble to form spherical micelles with ultralow (70 nmol/L) cmc's across a broad range of compositions.

Dual responsive polymeric nanoparticles prepared by direct functionalization of polylactic acid-based polymers via graft-from ring opening metathesis polymerization

Polylactic acid (PLA) has found widespread use in plastics and in biomedical applications due to its biodegradability into natural benign products. However, PLA-based materials remain limited in usefulness due to difficulty of incorporating functional groups into the polymer backbone. In this paper, we report a strategy for PLA functionalization that establishes the preparation of highly derivatized materials in which ring opening metathesis polymerization (ROMP) is employed as a graft-from polymerization technique utilizing a norbornene-modified handle incorporated into the PLA backbone. As a demonstration of this new synthetic methodology, a PLA-derived nanoparticle bearing imidazole units protected with a photolabile group was prepared. The morphology of this material could be controllably altered in response to exposure of UV light or acidic pH as a stimulus. We anticipate that this graft-from approach to derivatization of PLA could find broad use in the development of modified, biodegradable PLA-based materials.