677020-91-6

Basic information

• Product Name: Pyrazinecarboxamide, 5-(2-hydroxybenzoyl)-
• CAS NO: 677020-91-6
• Molecular Formula: C12H9N3O3
• Molecular Weight: 243.222
• Mol File: 677020-91-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyrazinecarboxamide, 5-(2-hydroxybenzoyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarboxamide, 5-(2-hydroxybenzoyl)-(677020-91-6)
• EPA Substance Registry System: Pyrazinecarboxamide, 5-(2-hydroxybenzoyl)-(677020-91-6)

Safety Data

• Hazardous Substances Data: 677020-91-6(Hazardous Substances Data)

Upstream product

• 98-96-4 pyrazinamide 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 677021-02-2 5-(2-hydroxy-benzoyl)-pyrazine-2-carboxylic acid 
• 677020-95-0 5-(2-hydroxy-benzoyl)-pyrazine-2-carbonitrile 

Relevant articles and documents

Substituted 5-aroylpyrazine-2-carboxylic acid derivatives: Synthesis and biological activity

Homolytic aroylation of pyrazine nucleus with various substituted aromatic carbaldehydes afforded a series of 5-aroylpyrazine-2-carboxylic acid derivatives. The synthetic approach, analytical and spectroscopic data of all compounds synthesized, their preliminary in vitro evaluation of antituberculotic and antifungal activities, cytotoxicity data and subsequent SAR studies are presented. Among all derivatives prepared, only 5-(4-chlorobenzoyl)-pyrazine-2-carbothioamide (3d) showed promising activity (90% inhibition) against Mycobacterium tuberculosis. The highest antifungal effect (MIC-1) against Trichophyton mentagrophytes, the most susceptible fungal strain tested, was found for 5-benzoylpyrazine-2-carbothioamide (3a). Thioamides exhibited higher in vitro antimicrobial activity than the corresponding amides.