677277-70-2

Basic information

• Product Name: Butanoic acid, 2-[(trifluoroacetyl)amino]-, (2S)-
• CAS NO: 677277-70-2
• Molecular Formula: C6H8F3NO3
• Molecular Weight: 199.13
• Mol File: 677277-70-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-[(trifluoroacetyl)amino]-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-[(trifluoroacetyl)amino]-, (2S)-(677277-70-2)
• EPA Substance Registry System: Butanoic acid, 2-[(trifluoroacetyl)amino]-, (2S)-(677277-70-2)

Safety Data

• Hazardous Substances Data: 677277-70-2(Hazardous Substances Data)

Upstream product

• 71-23-8 propan-1-ol 
• 5959-29-5 S-(+)-2-amino-n-butyric acid hydrochloride 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 677277-69-9 S-(-)-2-[N-(trifluoroacetyl)amino]-1-(2,5-dimethoxy-4-bromophenyl)-1-butanone 
• 1312303-91-5 N-[5-(2-aminophenyl)pent-4-ynyl]-2-(S)-(2,2,2-trifluoroacetylamino)butyramide 
• 1312762-59-6 (S)-benzyl 2-(2-(2,2,2-trifluoroacetamido)butanamido)ethylcarbamate 

Relevant articles and documents

ENANTIOSELECTIVE SYNTHESES OF α-AMINO ACIDS FROM 10-SULFONAMIDO-ISOBORNYL ESTERS AND DI-t-BUTYL AZODICARBOXYLATE

Successive treatment of chiral esters 7 with LDA/Me3SiCl and di-t-butyl azodicarboxylate/TiCl4 and Ti(OiPr)4 gave N,N-di-t-butoxycarbonylhydrazinoesters 11 which on deacylation, hydrogenolysis, transesterification and acidic hydrolysis furnished (2S)-α-amino acid hydrochlorides 13 in good overall yields, high enantiomeric purity and with efficient recovery of the alcohol auxiliary 4.Experimental evidence for the configuration and conformation of the intermediate O-silyl ketene acetals 1 is provided.