677306-38-6

Basic information

• Product Name: 1H-INDAZOLE-4-CARBOXYLIC ACID
• Synonyms: 1H-INDAZOLE-4-CARBOXYLIC ACID;4-INDAZOLECARBOXYLIC ACID;4-(1H)INDAZOLE CARBOXYLIC ACID;INDAZOLE-4-CARBOXYLIC ACID;Indazole-4-carboxylic aci...;4-Carboxy-1H-indazole;1H-Indazole-4-Carboxylic Acid(WX614188)
• CAS NO: 677306-38-6
• Molecular Formula: C₈H₆N₂O₂
• Molecular Weight: 162.15
• Product Categories: pharmacetical;Building Blocks;Indazole;Indazoles
• Mol File: 677306-38-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: ca 280℃
• Boiling Point: 443.749 °C at 760 mmHg
• Flash Point: 222.172 °C
• Appearance: White to cream/Crystalline Powder
• Density: 1.507g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.743
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 3.35±0.30(Predicted)
• CAS DataBase Reference: 1H-INDAZOLE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-INDAZOLE-4-CARBOXYLIC ACID(677306-38-6)
• EPA Substance Registry System: 1H-INDAZOLE-4-CARBOXYLIC ACID(677306-38-6)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 677306-38-6(Hazardous Substances Data)

Usage

General Description

1H-Indazole-4-Carboxylic Acid is a synthetic, organic chemical compound featuring an indazole core structure with a carboxyl functional group at the 4-position. Indazoles are heterocyclic aromatic compounds, which are commonly found in many natural products and synthetic compounds with a wide range of applications. Though not commonly used directly, 1H-Indazole-4-Carboxylic Acid often acts as an intermediate in synthesizing other complex chemical compounds and drugs. Its properties, such as solubility and reactivity, may vary based on its specific physical state or the presence of other chemicals. The compound should be handled with the standard safety precautions applied to lab chemicals due to its potentially reactive nature.

InChI:InChI=1/C8H6N2O2/c11-8(12)5-2-1-3-7-6(5)4-9-10-7/h1-4H,(H,9,10)(H,11,12)

Upstream product

• 18583-89-6 methyl 3-amino-2-methylbenzoate 
• 2258-42-6 formyl acetic anhydride 
• 186407-74-9 4-bromoindazole 
• 598-30-1 sec.-butyllithium 
• 192945-49-6 1H-indazole-4-carboxylic acid methyl ester 

Downstream Products

• 1194019-76-5 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 
• 1194018-05-7 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (pyridin-4-ylmethyl)-amide 
• 1194018-04-6 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (pyridin-3-ylmethyl)-amide 
• 1194018-03-5 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid (pyridin-2-ylmethyl)-amide 
• 1194017-89-4 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 4-(4-methyl-piperazine-1-sulfonyl)-benzylamide 
• 1194017-81-6 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 4-dimethylsulfamoyl-benzylamide 
• 1194017-82-7 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 4-isopropylsulfamoyl-benzylamide 
• 1194018-16-0 4-(methylsulfonyl)-benzyl 
• 1194018-55-7 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 3-dimethylsulfamoyl-benzylamide 
• 1194017-97-4 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 3-isopropylsulfamoyl-benzylamide 
• 1194017-96-3 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 3-ethylsulfamoyl-benzylamide 
• 1194018-54-6 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 3-methylsulfamoyl-benzylamide 
• 1194018-21-7 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 3-methanesulfonyl-benzylamide 
• 1194018-77-3 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid 3-methylcarbamoyl-benzylamide 

Relevant articles and documents

Cleavage of Carboxylic Esters by Aluminum and Iodine

A one-pot procedure for deprotecting carboxylic esters under nonhydrolytic conditions is described. Typical alkyl carboxylates are readily deblocked to the carboxylic acids by the action of aluminum powder and iodine in anhydrous acetonitrile. Cleavage of lactones affords the corresponding ω-iodoalkylcarboxylic acids. Aryl acetylates undergo deacetylation with the participation of the neighboring group. This method enables the selective cleavage of alkyl carboxylic esters in the presence of aryl esters.

Heteroaryl hydroxycarbonylation: An efficient, robust, practically scalable approach using formyl acetate as the co source

A simple, efficient, regioselective, and scalable palladium-catalyzed hydroxycarbonylation of heteroaryl halides to corresponding carboxylic acids using acetic-formic anhydride in presence of Pd(OAc)2, dppf, and diisopropylethyl amine in dimethyl formamide at 80-90 °C in excellent yields. Taylor & Francis Group, LLC.

HETEROAROMATIC UREAS WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I): are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).