67752-37-8

Basic information

• Product Name: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester
• Synonyms: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester;ethyl 1,2,3,4-tetrahydroquinoline-3-carboxylate;1,2,3,4-Tetrahydro-quinoline-3-carboxylic acid ethyl ester
• CAS NO: 67752-37-8
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.253
• Mol File: 67752-37-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester(67752-37-8)
• EPA Substance Registry System: 3-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, ethyl ester(67752-37-8)

Safety Data

• Hazardous Substances Data: 67752-37-8(Hazardous Substances Data)

Upstream product

• 34846-64-5 3-cyanoquinoline 
• 50741-46-3 ethyl 3-quinolinecarboxylate 
• 6480-68-8 quinoline-3-carboxylic acid 
• 114527-53-6 (-)-1,2,3,4-tetrahydroquinoline-3-carboxylic acid 
• 64-17-5 ethanol 

Downstream Products

• 1034770-89-2 Ethyl 1-benzyl-1,2,3,4-tetrahydroquinoline-3-carboxylate 

Relevant articles and documents

NMR studies of new heterocycles tethered to purine moieties with anticancer activity

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BETA-SECRETASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein A, B, R3, R4, R5, i and j are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use for these compounds, including treatment of AD and related diseases, by administering the compound(s) of Formula I, or compositions including them, to a subject. The invention also comprises further embodiments of Formulas II and III, intermediates and processes useful for the preparation of compounds of the invention.

Reduction of Quinolinecarboxylic Acids by Raney Alloy

The heterocyclic nucleus in quinolinecarboxylic acids is reduced by Raney alloy (nickel-aluminium) in alkaline media to give 1,2,3,4-tetrahydro-2-,3-,4-,5-,6-, and 8-quinolinecarboxylic acids and 8-methyl-5-quinolinecarboxylic acid and their ethyl esters.