678536-02-2

Basic information

• Product Name: C₁₆H₁₆N₂O₃
• Synonyms: C₁₆H₁₆N₂O₃
• CAS NO: 678536-02-2
• Molecular Weight: 284.315
• Mol File: 678536-02-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₆N₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₆N₂O₃(678536-02-2)
• EPA Substance Registry System: C₁₆H₁₆N₂O₃(678536-02-2)

Safety Data

• Hazardous Substances Data: 678536-02-2(Hazardous Substances Data)

Upstream product

• 7311-34-4 3,5-dimethoxybenzaldehdye 
• 613-94-5 benzoic acid hydrazide 
• 93-58-3 benzoic acid methyl ester 

Downstream Products

• 93014-11-0 2-(3,5-dimethoxyphenyl)-5-phenyl-1,3,4-oxadiazole 
• 1338091-89-6 (E)-N-allyl-N'-(3,5-dimethoxybenzylidene)benzohydrazide 
• 1338091-90-9 (E)-N-benzyl-N'-(3,5-dimethoxybenzylidene)benzohydrazide 

Relevant articles and documents

An efficient one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazoles from aldehydes and hydrazides using Lawesson’s reagent

Five-membered heterocyclic-ring systems, such as thiadiazoles, remain an important and prevalent scaffold in the development of novel leads in medicinal chemistry for a variety of therapeutic targets. A two-step, one-pot synthesis of 2,5-disubstituted-1,3,4-thiadiazole derivatives from aryl hydrazides and aryl aldehydes using Lawesson’s reagent is described, yielding 2,5-disubstituted-1,3,4-thiadiazoles in moderate-to-high yields. Based on preliminary biological experiments, some of the newly synthesized thiadiazoles show antioxidant activity.

Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill

A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones.