67900-19-0

Basic information

• Product Name: 4-MORPHOLIN-4-YL-4-OXO-BUTYRIC ACID
• Synonyms: AKOS BBS-00001411;4-MORPHOLIN-4-YL-4-OXO-BUTYRIC ACID;4-(4-MORPHOLINYL)-4-OXOBUTANOIC ACID;4-MORPHOLINO-4-OXOBUTANOIC ACID;4-MORPHOLIN-4-YL-4-OXO-BUTYRIC ACID >98%;4-Morpholinebutanoic acid, Gamma-oxo-;4-keto-4-morpholino-butyric acid;g-Oxo-4-morpholinebutanoic acid
• CAS NO: 67900-19-0
• Molecular Formula: C₈H₁₃NO₄
• Molecular Weight: 187.19
• Mol File: 67900-19-0.mol
• Article Data: 12

Chemical Properties

• Melting Point: 75-77 °C(Solv: benzene (71-43-2))
• Boiling Point: 420.3 °C at 760 mmHg
• Flash Point: 208 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 3.04E-08mmHg at 25°C
• Refractive Index: 1.503
• Storage Temp.: 2-8°C
• PKA: 4.94±0.17(Predicted)
• CAS DataBase Reference: 4-MORPHOLIN-4-YL-4-OXO-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MORPHOLIN-4-YL-4-OXO-BUTYRIC ACID(67900-19-0)
• EPA Substance Registry System: 4-MORPHOLIN-4-YL-4-OXO-BUTYRIC ACID(67900-19-0)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 67900-19-0(Hazardous Substances Data)

Usage

General Description

4-Morpholin-4-yl-4-oxo-butyric acid is a chemical compound that falls under the category of morpholines. Morpholines are organic chemical compounds that contain a six-membered ring with four carbon atoms and one nitrogen and one oxygen atom. This particular compound, with the addition of a carboxylic acid group and a ketone group, has a variety of potential uses. Studies exploring its properties and applications are still ongoing, but some potential areas of interest include pharmaceuticals, agrochemicals, and materials science. Its exact properties such as toxicity and reactivity would largely depend on the specific conditions under which it is used or stored.

InChI:InChI=1/C8H13NO4/c10-7(1-2-8(11)12)9-3-5-13-6-4-9/h1-6H2,(H,11,12)

Upstream product

• 110-91-8 morpholine 
• 108-55-4 glutaric anhydride, 
• 108-30-5 succinic acid anhydride 

Downstream Products

• 1383806-77-6 1-(7-phenoxyheptyl)-4-[4-[(morpholin-4-yl)-1,4-dioxo]butyl]piperazine 
• 1383806-52-7 1-(7-phenoxyheptyl)-4-[4-(morpholin-4-yl)butyl]piperazine 

Relevant articles and documents

Synthesis, characterization, interaction with anionic dye, biodegradability, and antimicrobial activity of cationic surfactants: quaternary hydrazinium derivatives

A novel cationic surfactant type of N'alkyl N,'N'dimethyl-4-morpholino-4-oxobutanoylhydrazinium iodide (10a–12a) and N'alkyl N', N'dimethyl-4-piperidino-4-oxobutanoylhydrazinium iodide (10b–12b) of quaternary hydrazinium moieties in hydrophilic parts was synthesized. These quaternary hydrazinium surfactants were obtained using a two-step reaction scheme, starting from ring opening of succinic anhydride with a base (morpholine, piperidine), followed by ammonolysis with hydrazine hydrate, then alkylation of the amino group with alkyl bromides (RBr) that have different hydrophobic chain lengths (R, C12H25, C14H29, and C16H37), and ending with the quaternarization of the secondary amino group by two moles of methyl iodide. The chemical composition of the surfactants was analyzed by FTIR, 1HNMR, mass spectroscopy, and elemental analysis. A variety of surface-active characteristics were achieved by surface calculations, including CMC, γcmc, CMC/C20, Γmax, pC20, Amin, and Πcmc. These surface characteristics and foam stability rely on the nature of the hydrophobic chain. Preliminary results showed that an upgrade throughout the CH2 group in the fatty chain and the morpholine or piperidine ring lowers the CMC and increases the foaming capacity and stability of the quaternary hydrazinium surfactants. Anionic dye (Acid BG) interactions with 12b surfactant (as an example) were studied using the spectrophotometric technique and the binding constant (170.64?dm3.mol?1) was determined. The results indicate solubilization and binding took place at a large scale. Furthermore, considerable biodegradation of cationic surfactants was observed (68–87%). The antimicrobial activity of these surfactants has also been observed with the minimum inhibitory concentration (MIC) and the size of inhibited growth zone. The smallest MICs were found in 12a (64?μg/mL) and 12b (32?μg/mL) surfactants, indicating the highest antimicrobial activity.

AGONISTS OF THE CHEMOKINE RECEPTOR CXCR3

The present invention relates to agonists of the chemokine receptor CXCR3, methods of their synthesis and uses thereof.

1-Phenoxyalkyl-4-[(N,N-disubstitutedamino)alkyl]piperazine derivatives as non-imidazole histamine H3-antagonists

In this study, a series of 1-phenoxyalkyl-4-[(N,N-disubstitutedamino)alkyl] piperazine derivatives has been prepared and in vitro tested as H 3-receptor antagonists (electrically evoked contraction of the guinea pig jejunum). All compounds inve